| 1 | |  Pachuca | 17 | 12 | 3 | 2 | 35 | 16 | 19 | 39 | M17:00 | 01/10/22 | R 17  CF Monterrey 3 Pachuca 1 G17:00 | 18/09/22 | R 15 Atletico San Luis 1 Pachuca 3 |
| 2 | |  Atlas | 17 | 11 | 3 | 3 | 30 | 17 | 13 | 36 | |
| 3 | |  Tigres UANL | 17 | 9 | 6 | 2 | 26 | 14 | 12 | 33 | B17:00 | 01/10/22 | R 17 Atletico San Luis 2 Tigres UANL 2 G17:00 | 28/09/22 | R 3 Tigres UANL 3 Club Tijuana de Caliente 0 M17:00 | 24/09/22 | R 4 Tigres UANL 0 Atlas 1 G17:00 | 21/09/22 | R 11 Tigres UANL 3 Necaxa 0 |
| 4 | |  Club America | 17 | 8 | 7 | 2 | 34 | 19 | 15 | 31 | B17:00 | 30/09/22 | R 17 Puebla 1 Club America 1 B17:00 | 17/09/22 | R 15 Club America 2 Chivas Guadalajara 2 |
| 5 | |  Club Leon | 17 | 9 | 3 | 5 | 30 | 25 | 5 | 30 | G17:00 | 02/10/22 | R 17 Club Leon 1 Club Tijuana de Caliente 0 G17:00 | 27/09/22 | R 8 Club Leon 4 Mazatlan FC 1 G18:30 | 18/09/22 | R 15 Club Leon 3 Queretaro FC 2 B17:00 | 15/09/22 | R 16 Cruz Azul 1 Club Leon 1 |
| 6 | |  Pumas Unam | 17 | 9 | 2 | 6 | 26 | 17 | 9 | 29 | |
| 7 | |  Puebla | 17 | 7 | 6 | 4 | 30 | 27 | 3 | 27 | B17:00 | 30/09/22 | R 17 Puebla 1 Club America 1 B17:00 | 22/09/22 | R 5 CF Monterrey 3 Puebla 3 B17:00 | 16/09/22 | R 15 Puebla 1 Tigres UANL 1 G17:00 | 13/09/22 | R 9 Puebla 3 Necaxa 2 |
| 8 | |  Club Santos Laguna | 17 | 7 | 5 | 5 | 32 | 27 | 5 | 26 | M19:00 | 02/10/22 | R 17 Club Santos Laguna 2 Mazatlan FC 3 M17:00 | 22/09/22 | R 4 Deportivo Toluca FC 1 Club Santos Laguna 0 G19:00 | 18/09/22 | R 15 Club Santos Laguna 3 FC Juarez 0 M17:00 | 14/09/22 | R 5 Club America 1 Club Santos Laguna 0 |
| 9 | |  FC Juarez | 17 | 7 | 3 | 7 | 21 | 26 | -5 | 24 | G18:00 | 30/09/22 | R 17 FC Juarez 3 Pumas Unam 0 G18:00 | 23/09/22 | R 16 FC Juarez 3 Atletico San Luis 0 M19:00 | 18/09/22 | R 15 Club Santos Laguna 3 FC Juarez 0 G18:00 | 14/09/22 | R 8 FC Juarez 1 Pachuca 0 M18:00 | 09/09/22 | R 14 FC Juarez 1 CF Monterrey 3 M17:00 | 06/09/22 | R 13 Club Leon 3 FC Juarez 1 |
| 10 | |  Chivas Guadalajara | 17 | 4 | 8 | 5 | 23 | 21 | 2 | 20 | B17:00 | 01/10/22 | R 17 Cruz Azul 1 Chivas Guadalajara 1 G17:00 | 28/09/22 | R 16 Chivas Guadalajara 3 CF Monterrey 0 B17:00 | 17/09/22 | R 15 Club America 2 Chivas Guadalajara 2 G17:00 | 13/09/22 | R 9 Chivas Guadalajara 1 Tigres UANL 0 B17:00 | 10/09/22 | R 14 Chivas Guadalajara 1 Puebla 1 B01:45 | 08/09/22 | R 13 Club Tijuana de Caliente 1 Chivas Guadalajara 1 |
| 11 | |  Mazatlan FC | 17 | 6 | 2 | 9 | 29 | 34 | -5 | 20 | G19:00 | 02/10/22 | R 17 Club Santos Laguna 2 Mazatlan FC 3 M17:00 | 27/09/22 | R 8 Club Leon 4 Mazatlan FC 1 M17:00 | 24/09/22 | R 16 Necaxa 2 Mazatlan FC 0 G18:00 | 20/09/22 | R 13 Mazatlan FC 4 Atlas 0 G18:00 | 16/09/22 | R 15 Mazatlan FC 1 Deportivo Toluca FC 0 G17:00 | 11/09/22 | R 14 Cruz Azul 1 Mazatlan FC 2 |
| 12 | |  Necaxa | 17 | 5 | 4 | 8 | 29 | 30 | -1 | 19 | M17:00 | 01/10/22 | R 17 Atlas 2 Necaxa 1 G17:00 | 24/09/22 | R 16 Necaxa 2 Mazatlan FC 0 M17:00 | 21/09/22 | R 11 Tigres UANL 3 Necaxa 0 G01:45 | 19/09/22 | R 15 Club Tijuana de Caliente 2 Necaxa 3 M17:00 | 13/09/22 | R 9 Puebla 3 Necaxa 2 M17:00 | 10/09/22 | R 14 Necaxa 1 Club America 2 |
| 13 | |  Cruz Azul | 17 | 5 | 3 | 9 | 17 | 21 | -4 | 18 | B17:00 | 01/10/22 | R 17 Cruz Azul 1 Chivas Guadalajara 1 M17:00 | 18/09/22 | R 15 Pumas Unam 2 Cruz Azul 0 B17:00 | 15/09/22 | R 16 Cruz Azul 1 Club Leon 1 M17:00 | 11/09/22 | R 14 Cruz Azul 1 Mazatlan FC 2 M17:00 | 06/09/22 | R 13 CF Monterrey 4 Cruz Azul 2 G18:00 | 02/09/22 | R 12 FC Juarez 0 Cruz Azul 3 |
| 14 | |  CF Monterrey | 17 | 5 | 3 | 9 | 25 | 30 | -5 | 18 | G17:00 | 01/10/22 | R 17 CF Monterrey 3 Pachuca 1 M17:00 | 28/09/22 | R 16 Chivas Guadalajara 3 CF Monterrey 0 B17:00 | 22/09/22 | R 5 CF Monterrey 3 Puebla 3 M17:00 | 17/09/22 | R 15 CF Monterrey 0 Atlas 1 G18:00 | 09/09/22 | R 14 FC Juarez 1 CF Monterrey 3 G17:00 | 06/09/22 | R 13 CF Monterrey 4 Cruz Azul 2 |
| 15 | |  Atletico San Luis | 17 | 5 | 2 | 10 | 25 | 45 | -20 | 17 | B17:00 | 01/10/22 | R 17 Atletico San Luis 2 Tigres UANL 2 M18:00 | 23/09/22 | R 16 FC Juarez 3 Atletico San Luis 0 M17:00 | 18/09/22 | R 15 Atletico San Luis 1 Pachuca 3 M17:00 | 11/09/22 | R 14 Atlas 3 Atletico San Luis 0 M17:00 | 06/09/22 | R 13 Club America 5 Atletico San Luis 0 G17:00 | 01/09/22 | R 12 Atletico San Luis 3 Club Tijuana de Caliente 2 |
| 16 | |  Deportivo Toluca FC | 17 | 3 | 4 | 10 | 15 | 29 | -14 | 13 | B17:00 | 02/10/22 | R 17 Deportivo Toluca FC 2 Queretaro FC 2 G17:00 | 22/09/22 | R 4 Deportivo Toluca FC 1 Club Santos Laguna 0 M18:00 | 16/09/22 | R 15 Mazatlan FC 1 Deportivo Toluca FC 0 M17:00 | 10/09/22 | R 14 Deportivo Toluca FC 1 Pumas Unam 2 M17:00 | 07/09/22 | R 13 Tigres UANL 1 Deportivo Toluca FC 0 G17:00 | 04/09/22 | R 12 Deportivo Toluca FC 1 Chivas Guadalajara 0 |
| 17 | |  Club Tijuana de Caliente | 17 | 1 | 8 | 8 | 21 | 35 | -14 | 11 | M17:00 | 02/10/22 | R 17 Club Leon 1 Club Tijuana de Caliente 0 M17:00 | 28/09/22 | R 3 Tigres UANL 3 Club Tijuana de Caliente 0 M01:45 | 19/09/22 | R 15 Club Tijuana de Caliente 2 Necaxa 3 M20:00 | 11/09/22 | R 14 Pachuca 4 Club Tijuana de Caliente 0 B01:45 | 08/09/22 | R 13 Club Tijuana de Caliente 1 Chivas Guadalajara 1 M17:00 | 01/09/22 | R 12 Atletico San Luis 3 Club Tijuana de Caliente 2 |
| 18 | |  Queretaro FC | 17 | 1 | 6 | 10 | 16 | 31 | -15 | 9 | B17:00 | 02/10/22 | R 17 Deportivo Toluca FC 2 Queretaro FC 2 M18:30 | 18/09/22 | R 15 Club Leon 3 Queretaro FC 2 B17:00 | 10/09/22 | R 14 Queretaro FC 2 Club Santos Laguna 2 M17:00 | 07/09/22 | R 13 Pumas Unam 2 Queretaro FC 0 M17:00 | 01/09/22 | R 12 Queretaro FC 0 Puebla 2 M17:00 | 27/08/22 | R 11 Cruz Azul 3 Queretaro FC 1 |
