| 1 | |  Pachuca | 17 | 10 | 4 | 3 | 37 | 22 | 15 | 34 | |
| 2 | |  Monterrey | 16 | 11 | 1 | 4 | 30 | 18 | 12 | 34 | |
| 3 | |  America Mexico | 16 | 10 | 2 | 4 | 28 | 12 | 16 | 32 | G19:30 | 01/05/21 | R 17  Pumas Unam 0 America Mexico 1 G17:00 | 25/04/21 | R 16 Deportivo Toluca FC 0 America Mexico 2 G19:00 | 17/04/21 | R 15 America Mexico 4 Cruz Azul 1 G17:00 | 10/04/21 | R 14 Tigres 1 America Mexico 2 |
| 4 | |  Club Tijuana de Caliente | 17 | 10 | 1 | 6 | 26 | 16 | 10 | 31 | G17:00 | 01/05/21 | R 17 Cruz Azul 0 Club Tijuana de Caliente 1 G01:45 | 24/04/21 | R 16 Club Tijuana de Caliente 3 Necaxa 1 M17:00 | 17/04/21 | R 15 Chivas Guadalajara 2 Club Tijuana de Caliente 1 G01:45 | 12/04/21 | R 14 Club Tijuana de Caliente 1 Mazatlan FC 0 |
| 5 | |  Deportivo Toluca FC | 17 | 8 | 4 | 5 | 29 | 20 | 9 | 28 | B17:00 | 30/04/21 | R 17 FC Juarez 0 Deportivo Toluca FC 0 M17:00 | 25/04/21 | R 16 Deportivo Toluca FC 0 America Mexico 2 |
| 6 | |  Atlas | 17 | 8 | 4 | 5 | 25 | 19 | 6 | 28 | B17:00 | 30/04/21 | R 17 Necaxa 2 Atlas 2 G17:00 | 24/04/21 | R 16 Atlas 3 Chivas Guadalajara 2 |
| 7 | |  FC Juarez | 16 | 7 | 4 | 5 | 18 | 18 | 0 | 25 | B17:00 | 30/04/21 | R 17 FC Juarez 0 Deportivo Toluca FC 0 G17:00 | 25/04/21 | R 16 Queretaro 0 FC Juarez 2 G17:00 | 19/04/21 | R 15 Leon 1 FC Juarez 2 M17:00 | 14/04/21 | R 5 FC Juarez 0 Tigres 1 |
| 8 | |  Leon | 16 | 8 | 1 | 7 | 26 | 29 | -3 | 25 | G17:00 | 01/05/21 | R 17 Leon 3 Queretaro 0 G18:00 | 23/04/21 | R 16 Mazatlan FC 1 Leon 3 M17:00 | 19/04/21 | R 15 Leon 1 FC Juarez 2 |
| 9 | |  Puebla | 17 | 8 | 0 | 9 | 35 | 42 | -7 | 24 | G19:00 | 02/05/21 | R 17 Club Santos Laguna 2 Puebla 3 G17:00 | 23/04/21 | R 16 Puebla 3 Pumas Unam 2 M18:00 | 17/04/21 | R 15 Atletico San Luis 5 Puebla 3 M20:00 | 12/04/21 | R 14 Pachuca 5 Puebla 2 M17:00 | 07/04/21 | R 4 Puebla 2 Monterrey 3 G18:00 | 02/04/21 | R 13 Puebla 6 Mazatlan FC 2 |
| 10 | |  Tigres | 17 | 6 | 5 | 6 | 27 | 20 | 7 | 23 | B17:00 | 01/05/21 | R 17 Chivas Guadalajara 1 Tigres 1 B17:00 | 24/04/21 | R 16 Tigres 2 Monterrey 2 G17:00 | 18/04/21 | R 15 Pumas Unam 2 Tigres 4 G17:00 | 14/04/21 | R 5 FC Juarez 0 Tigres 1 M17:00 | 10/04/21 | R 14 Tigres 1 America Mexico 2 G17:00 | 04/04/21 | R 13 Queretaro 1 Tigres 4 |
| 11 | |  Mazatlan FC | 17 | 6 | 4 | 7 | 26 | 30 | -4 | 22 | M17:00 | 01/05/21 | R 17 Monterrey 2 Mazatlan FC 0 M18:00 | 23/04/21 | R 16 Mazatlan FC 1 Leon 3 B18:00 | 16/04/21 | R 15 Mazatlan FC 2 Atlas 2 M01:45 | 12/04/21 | R 14 Club Tijuana de Caliente 1 Mazatlan FC 0 M18:00 | 02/04/21 | R 13 Puebla 6 Mazatlan FC 2 G19:00 | 19/03/21 | R 12 Mazatlan FC 1 America Mexico 0 |
| 12 | |  Atletico San Luis | 17 | 7 | 1 | 9 | 25 | 34 | -9 | 22 | G18:00 | 29/04/21 | R 17 Atletico San Luis 2 Pachuca 0 G19:45 | 24/04/21 | R 16 Cruz Azul 0 Atletico San Luis 1 G18:00 | 17/04/21 | R 15 Atletico San Luis 5 Puebla 3 B17:00 | 09/04/21 | R 14 FC Juarez 2 Atletico San Luis 2 M18:00 | 03/04/21 | R 13 Monterrey 4 Atletico San Luis 1 M19:00 | 26/03/21 | R 4 Leon 4 Atletico San Luis 2 |
| 13 | |  Chivas Guadalajara | 17 | 6 | 2 | 9 | 28 | 29 | -1 | 20 | B17:00 | 01/05/21 | R 17 Chivas Guadalajara 1 Tigres 1 M17:00 | 24/04/21 | R 16 Atlas 3 Chivas Guadalajara 2 G17:00 | 17/04/21 | R 15 Chivas Guadalajara 2 Club Tijuana de Caliente 1 G17:00 | 10/04/21 | R 14 Cruz Azul 0 Chivas Guadalajara 1 G17:00 | 04/04/21 | R 13 Chivas Guadalajara 5 Club Santos Laguna 2 G18:00 | 27/03/21 | R 1 Puebla 2 Chivas Guadalajara 4 |
| 14 | |  Club Santos Laguna | 16 | 4 | 5 | 7 | 24 | 23 | 1 | 17 | M19:00 | 02/05/21 | R 17 Club Santos Laguna 2 Puebla 3 M20:00 | 26/04/21 | R 16 Pachuca 3 Club Santos Laguna 1 B19:00 | 18/04/21 | R 15 Club Santos Laguna 2 Deportivo Toluca FC 2 M17:00 | 11/04/21 | R 14 Queretaro 1 Club Santos Laguna 0 M17:00 | 04/04/21 | R 13 Chivas Guadalajara 5 Club Santos Laguna 2 G20:00 | 21/03/21 | R 12 Club Santos Laguna 3 Leon 0 |
| 15 | |  Necaxa | 17 | 4 | 4 | 9 | 19 | 26 | -7 | 16 | B17:00 | 30/04/21 | R 17 Necaxa 2 Atlas 2 M01:45 | 24/04/21 | R 16 Club Tijuana de Caliente 3 Necaxa 1 G17:00 | 16/04/21 | R 15 Necaxa 4 Queretaro 1 G17:00 | 09/04/21 | R 14 Necaxa 1 Pumas Unam 0 M20:00 | 03/04/21 | R 13 America Mexico 1 Necaxa 0 M18:00 | 19/03/21 | R 12 Necaxa 2 FC Juarez 4 |
| 16 | |  Pumas Unam | 17 | 4 | 4 | 9 | 24 | 34 | -10 | 16 | M19:30 | 01/05/21 | R 17 Pumas Unam 0 America Mexico 1 M17:00 | 23/04/21 | R 16 Puebla 3 Pumas Unam 2 M17:00 | 18/04/21 | R 15 Pumas Unam 2 Tigres 4 M17:00 | 09/04/21 | R 14 Necaxa 1 Pumas Unam 0 B17:00 | 04/04/21 | R 13 Pumas Unam 4 Pachuca 4 M19:00 | 20/03/21 | R 12 Atletico San Luis 2 Pumas Unam 1 |
| 17 | |  Cruz Azul | 16 | 4 | 3 | 9 | 10 | 24 | -14 | 15 | M17:00 | 01/05/21 | R 17 Cruz Azul 0 Club Tijuana de Caliente 1 M19:45 | 24/04/21 | R 16 Cruz Azul 0 Atletico San Luis 1 M19:00 | 17/04/21 | R 15 America Mexico 4 Cruz Azul 1 M17:00 | 10/04/21 | R 14 Cruz Azul 0 Chivas Guadalajara 1 B20:00 | 07/04/21 | R 3 Pachuca 0 Cruz Azul 0 G19:00 | 02/04/21 | R 13 FC Juarez 0 Cruz Azul 1 |
| 18 | |  Queretaro | 17 | 4 | 1 | 12 | 13 | 34 | -21 | 13 | M17:00 | 01/05/21 | R 17 Leon 3 Queretaro 0 M17:00 | 25/04/21 | R 16 Queretaro 0 FC Juarez 2 M17:00 | 16/04/21 | R 15 Necaxa 4 Queretaro 1 G17:00 | 11/04/21 | R 14 Queretaro 1 Club Santos Laguna 0 M17:00 | 04/04/21 | R 13 Queretaro 1 Tigres 4 M00:45 | 21/03/21 | R 12 Club Tijuana de Caliente 1 Queretaro 0 |
