| 1 | |  Panathinaikos | 24 | 17 | 2 | 5 | 49 | 24 | 25 | 53 | G12:00 | 09/04/22 | R 21  OFI 0 Panathinaikos 3 G13:00 | 26/03/22 | R 18 Panathinaikos 1 Olympiacos FC 0 G13:00 | 20/03/22 | R 17 Volos NPS 2 Panathinaikos 4 G15:00 | 12/03/22 | R 16 Panathinaikos 1 Aris 0 G13:00 | 05/03/22 | R 26 Atromitos Athinon 0 Panathinaikos 2 G12:00 | 19/02/22 | R 24 Panaitolikos 0 Panathinaikos 1 |
| 2 | |  Asteras Tripolis | 24 | 14 | 6 | 4 | 43 | 23 | 20 | 48 | G15:00 | 09/04/22 | R 21 Asteras Tripolis 2 Pas Giannina 0 M12:30 | 02/04/22 | R 17 Olympiacos FC 3 Asteras Tripolis 1 G11:00 | 27/03/22 | R 18 Asteras Tripolis 3 Volos NPS 0 M14:30 | 12/03/22 | R 16 Asteras Tripolis 1 OFI 3 G12:00 | 26/02/22 | R 25 Asteras Tripolis 1 Aris 0 G13:15 | 19/02/22 | R 24 Atromitos Athinon 1 Asteras Tripolis 2 |
| 3 | |  PAOK Thessaloniki | 24 | 14 | 5 | 5 | 41 | 20 | 21 | 47 | B12:00 | 09/04/22 | R 21 Apollon Smirnis 0 PAOK Thessaloniki 0 M11:00 | 03/04/22 | R 24 Aris 1 PAOK Thessaloniki 0 G17:00 | 26/03/22 | R 18 PAOK Thessaloniki 4 OFI 1 M13:00 | 17/03/22 | R 14 Pas Giannina 3 PAOK Thessaloniki 1 G12:00 | 13/03/22 | R 16 PAOK Thessaloniki 2 Panaitolikos 0 G13:00 | 06/03/22 | R 26 Lamia 1964 1 PAOK Thessaloniki 2 |
| 4 | |  Pas Giannina | 24 | 12 | 6 | 6 | 37 | 27 | 10 | 42 | M15:00 | 09/04/22 | R 21 Asteras Tripolis 2 Pas Giannina 0 M11:00 | 27/03/22 | R 18 Pas Giannina 0 Atromitos Athinon 1 B14:30 | 20/03/22 | R 17 OFI 3 Pas Giannina 3 G13:00 | 17/03/22 | R 14 Pas Giannina 3 PAOK Thessaloniki 1 G12:00 | 13/03/22 | R 16 Pas Giannina 2 Ionikos Nikea U19 1 B16:00 | 05/03/22 | R 26 Volos NPS 0 Pas Giannina 0 |
| 5 | |  Aris | 24 | 12 | 4 | 8 | 39 | 30 | 9 | 40 | G11:00 | 03/04/22 | R 24 Aris 1 PAOK Thessaloniki 0 M12:00 | 26/03/22 | R 18 Apollon Smirnis 2 Aris 0 B12:00 | 20/03/22 | R 17 Aris 2 Atromitos Athinon 2 M15:00 | 12/03/22 | R 16 Panathinaikos 1 Aris 0 G13:00 | 06/03/22 | R 26 Aris 3 Olympiacos FC 1 M12:00 | 26/02/22 | R 25 Asteras Tripolis 1 Aris 0 |
| 6 | |  Apollon Smirnis | 24 | 9 | 8 | 7 | 29 | 25 | 4 | 35 | B12:00 | 09/04/22 | R 21 Apollon Smirnis 0 PAOK Thessaloniki 0 G12:00 | 26/03/22 | R 18 Apollon Smirnis 2 Aris 0 B13:00 | 19/03/22 | R 17 Ionikos Nikea U19 1 Apollon Smirnis 1 G12:00 | 12/03/22 | R 16 Apollon Smirnis 3 Olympiacos FC 2 G13:00 | 05/03/22 | R 26 OFI 0 Apollon Smirnis 1 M12:00 | 02/03/22 | R 13 Apollon Smirnis 0 OFI 1 |
| 7 | |  Atromitos Athinon | 24 | 9 | 8 | 7 | 32 | 32 | 0 | 35 | G13:30 | 09/04/22 | R 21 Atromitos Athinon 1 Lamia 1964 0 G11:00 | 27/03/22 | R 18 Pas Giannina 0 Atromitos Athinon 1 B12:00 | 20/03/22 | R 17 Aris 2 Atromitos Athinon 2 B16:00 | 12/03/22 | R 16 Atromitos Athinon 3 Volos NPS 3 M13:00 | 05/03/22 | R 26 Atromitos Athinon 0 Panathinaikos 2 M11:30 | 26/02/22 | R 25 Apollon Smirnis 2 Atromitos Athinon 0 |
| 8 | |  Olympiacos FC | 24 | 10 | 3 | 11 | 40 | 31 | 9 | 33 | G14:30 | 10/04/22 | R 21 Olympiacos FC 4 Panaitolikos 1 G17:30 | 06/04/22 | R 22 Ionikos Nikea U19 1 Olympiacos FC 2 G12:30 | 02/04/22 | R 17 Olympiacos FC 3 Asteras Tripolis 1 M13:00 | 26/03/22 | R 18 Panathinaikos 1 Olympiacos FC 0 M12:00 | 12/03/22 | R 16 Apollon Smirnis 3 Olympiacos FC 2 M13:00 | 06/03/22 | R 26 Aris 3 Olympiacos FC 1 |
| 9 | |  Ionikos Nikea U19 | 24 | 7 | 6 | 11 | 32 | 33 | -1 | 27 | B13:30 | 10/04/22 | R 21 Volos NPS 1 Ionikos Nikea U19 1 M17:30 | 06/04/22 | R 22 Ionikos Nikea U19 1 Olympiacos FC 2 G14:00 | 26/03/22 | R 18 Lamia 1964 1 Ionikos Nikea U19 3 B13:00 | 19/03/22 | R 17 Ionikos Nikea U19 1 Apollon Smirnis 1 M12:00 | 13/03/22 | R 16 Pas Giannina 2 Ionikos Nikea U19 1 G16:00 | 05/03/22 | R 26 Ionikos Nikea U19 2 Panaitolikos 0 |
| 10 | |  OFI | 24 | 6 | 7 | 11 | 27 | 43 | -16 | 25 | M12:00 | 09/04/22 | R 21 OFI 0 Panathinaikos 3 M17:00 | 26/03/22 | R 18 PAOK Thessaloniki 4 OFI 1 B14:30 | 20/03/22 | R 17 OFI 3 Pas Giannina 3 G13:30 | 16/03/22 | R 23 OFI 2 Volos NPS 0 G14:30 | 12/03/22 | R 16 Asteras Tripolis 1 OFI 3 M13:00 | 05/03/22 | R 26 OFI 0 Apollon Smirnis 1 |
| 11 | |  Panaitolikos | 24 | 5 | 6 | 13 | 30 | 44 | -14 | 21 | M14:30 | 10/04/22 | R 21 Olympiacos FC 4 Panaitolikos 1 G16:30 | 20/03/22 | R 17 Panaitolikos 5 Lamia 1964 2 M12:00 | 13/03/22 | R 16 PAOK Thessaloniki 2 Panaitolikos 0 M16:00 | 05/03/22 | R 26 Ionikos Nikea U19 2 Panaitolikos 0 B12:00 | 27/02/22 | R 25 Panaitolikos 3 Volos NPS 3 M12:00 | 19/02/22 | R 24 Panaitolikos 0 Panathinaikos 1 |
| 12 | |  Volos NPS | 24 | 2 | 8 | 14 | 16 | 48 | -32 | 14 | B13:30 | 10/04/22 | R 21 Volos NPS 1 Ionikos Nikea U19 1 M11:00 | 27/03/22 | R 18 Asteras Tripolis 3 Volos NPS 0 M13:00 | 20/03/22 | R 17 Volos NPS 2 Panathinaikos 4 M13:30 | 16/03/22 | R 23 OFI 2 Volos NPS 0 B16:00 | 12/03/22 | R 16 Atromitos Athinon 3 Volos NPS 3 B16:00 | 05/03/22 | R 26 Volos NPS 0 Pas Giannina 0 |
| 13 | |  Lamia 1964 | 24 | 1 | 7 | 16 | 15 | 50 | -35 | 10 | M13:30 | 09/04/22 | R 21 Atromitos Athinon 1 Lamia 1964 0 M14:00 | 26/03/22 | R 18 Lamia 1964 1 Ionikos Nikea U19 3 M16:30 | 20/03/22 | R 17 Panaitolikos 5 Lamia 1964 2 M13:00 | 06/03/22 | R 26 Lamia 1964 1 PAOK Thessaloniki 2 M16:00 | 26/02/22 | R 25 Pas Giannina 2 Lamia 1964 1 B16:00 | 21/02/22 | R 24 Lamia 1964 0 Apollon Smirnis 0 |
