| 1 | |  Trencin | 26 | 19 | 2 | 5 | 68 | 22 | 46 | 59 | G12:00 | 28/05/22 | R 26  Ruzomberok 0 Trencin 2 G12:00 | 22/05/22 | R 25 Trencin 2 Slovan Bratislava 0 G12:00 | 14/05/22 | R 24 FC Petrzalka U19 1 Trencin 2 G12:00 | 01/05/22 | R 23 Trencin 3 FC Kosice 0 G12:00 | 24/04/22 | R 22 Trencin 5 ZP Sport Podbrezova 0 G12:00 | 10/04/22 | R 21 Zemplin Michalovce 3 Trencin 4 |
| 2 | |  MSK Zilina | 26 | 17 | 4 | 5 | 56 | 27 | 29 | 55 | B12:00 | 28/05/22 | R 26 MSK Zilina 2 ZP Sport Podbrezova 2 G12:00 | 22/05/22 | R 25 Zemplin Michalovce 1 MSK Zilina 2 G14:30 | 11/05/22 | R 24 MSK Zilina 2 Senica 0 G12:00 | 30/04/22 | R 23 Nitra 1 MSK Zilina 2 G12:00 | 23/04/22 | R 22 MSK Zilina 3 FC Dac 1904 Dunajska Streda 1 B12:00 | 14/04/22 | R 16 Slovan Bratislava 0 MSK Zilina 0 |
| 3 | |  Spartak Trnava | 26 | 17 | 3 | 6 | 47 | 30 | 17 | 54 | G12:00 | 28/05/22 | R 26 Spartak Trnava 4 Nitra 0 M12:00 | 22/05/22 | R 25 FC Dac 1904 Dunajska Streda 7 Spartak Trnava 0 G12:00 | 14/05/22 | R 24 FC Kosice 0 Spartak Trnava 3 G12:00 | 30/04/22 | R 23 Spartak Trnava 4 MFk Dukla Banska Bystrica 2 G12:00 | 23/04/22 | R 22 FK Poprad U19 0 Spartak Trnava 2 G12:00 | 09/04/22 | R 21 Spartak Trnava 1 MSK Zilina 0 |
| 4 | |  Slovan Bratislava | 26 | 14 | 6 | 6 | 56 | 30 | 26 | 48 | G12:00 | 28/05/22 | R 26 Slovan Bratislava 4 FC Petrzalka U19 1 M12:00 | 22/05/22 | R 25 Trencin 2 Slovan Bratislava 0 G17:00 | 14/05/22 | R 24 Slovan Bratislava 3 ZP Sport Podbrezova 1 G17:00 | 05/05/22 | R 22 Slovan Bratislava 1 Senica 0 M12:00 | 01/05/22 | R 23 Zemplin Michalovce 3 Slovan Bratislava 1 B12:00 | 14/04/22 | R 16 Slovan Bratislava 0 MSK Zilina 0 |
| 5 | |  FC Dac 1904 Dunajska Streda | 26 | 13 | 5 | 8 | 64 | 36 | 28 | 44 | B19:00 | 27/05/22 | R 26 FC Kosice 2 FC Dac 1904 Dunajska Streda 2 G12:00 | 22/05/22 | R 25 FC Dac 1904 Dunajska Streda 7 Spartak Trnava 0 M12:00 | 14/05/22 | R 24 MFk Dukla Banska Bystrica 3 FC Dac 1904 Dunajska Streda 1 B14:00 | 30/04/22 | R 23 FC Dac 1904 Dunajska Streda 1 FK Poprad U19 1 M12:00 | 23/04/22 | R 22 MSK Zilina 3 FC Dac 1904 Dunajska Streda 1 G12:00 | 09/04/22 | R 21 FC Dac 1904 Dunajska Streda 2 Ruzomberok 0 |
| 6 | |  FC Kosice | 26 | 12 | 7 | 7 | 34 | 31 | 3 | 43 | B19:00 | 27/05/22 | R 26 FC Kosice 2 FC Dac 1904 Dunajska Streda 2 G12:00 | 21/05/22 | R 25 FC Petrzalka U19 0 FC Kosice 4 M12:00 | 14/05/22 | R 24 FC Kosice 0 Spartak Trnava 3 M12:00 | 01/05/22 | R 23 Trencin 3 FC Kosice 0 B12:00 | 23/04/22 | R 22 FC Kosice 0 MFk Dukla Banska Bystrica 0 G12:00 | 09/04/22 | R 21 ZP Sport Podbrezova 1 FC Kosice 2 |
| 7 | |  MFk Dukla Banska Bystrica | 26 | 11 | 6 | 9 | 45 | 30 | 15 | 39 | G12:00 | 28/05/22 | R 26 MFk Dukla Banska Bystrica 1 Senica 0 G12:00 | 22/05/22 | R 25 Nitra 0 MFk Dukla Banska Bystrica 1 G12:00 | 14/05/22 | R 24 MFk Dukla Banska Bystrica 3 FC Dac 1904 Dunajska Streda 1 M12:00 | 30/04/22 | R 23 Spartak Trnava 4 MFk Dukla Banska Bystrica 2 B12:00 | 23/04/22 | R 22 FC Kosice 0 MFk Dukla Banska Bystrica 0 G12:00 | 08/04/22 | R 21 MFk Dukla Banska Bystrica 10 FK Poprad U19 0 |
| 8 | |  Zemplin Michalovce | 26 | 11 | 3 | 12 | 36 | 38 | -2 | 36 | G12:00 | 28/05/22 | R 26 FK Poprad U19 1 Zemplin Michalovce 2 M12:00 | 22/05/22 | R 25 Zemplin Michalovce 1 MSK Zilina 2 M15:00 | 14/05/22 | R 24 Ruzomberok 3 Zemplin Michalovce 0 G12:00 | 01/05/22 | R 23 Zemplin Michalovce 3 Slovan Bratislava 1 G12:00 | 23/04/22 | R 22 FC Petrzalka U19 0 Zemplin Michalovce 2 M12:00 | 10/04/22 | R 21 Zemplin Michalovce 3 Trencin 4 |
| 9 | |  Ruzomberok | 26 | 10 | 3 | 13 | 43 | 50 | -7 | 33 | M12:00 | 28/05/22 | R 26 Ruzomberok 0 Trencin 2 M12:00 | 22/05/22 | R 25 ZP Sport Podbrezova 2 Ruzomberok 1 G15:00 | 14/05/22 | R 24 Ruzomberok 3 Zemplin Michalovce 0 M12:00 | 08/05/22 | R 23 Senica 2 Ruzomberok 0 G12:00 | 23/04/22 | R 22 Ruzomberok 2 Nitra 0 M12:00 | 09/04/22 | R 21 FC Dac 1904 Dunajska Streda 2 Ruzomberok 0 |
| 10 | |  FC Petrzalka U19 | 26 | 9 | 3 | 14 | 24 | 48 | -24 | 30 | M12:00 | 28/05/22 | R 26 Slovan Bratislava 4 FC Petrzalka U19 1 M12:00 | 21/05/22 | R 25 FC Petrzalka U19 0 FC Kosice 4 M12:00 | 14/05/22 | R 24 FC Petrzalka U19 1 Trencin 2 G13:30 | 07/05/22 | R 23 ZP Sport Podbrezova 0 FC Petrzalka U19 1 M12:00 | 23/04/22 | R 22 FC Petrzalka U19 0 Zemplin Michalovce 2 G12:00 | 10/04/22 | R 21 Senica 0 FC Petrzalka U19 1 |
| 11 | |  ZP Sport Podbrezova | 26 | 7 | 4 | 15 | 37 | 47 | -10 | 25 | B12:00 | 28/05/22 | R 26 MSK Zilina 2 ZP Sport Podbrezova 2 G12:00 | 22/05/22 | R 25 ZP Sport Podbrezova 2 Ruzomberok 1 M17:00 | 14/05/22 | R 24 Slovan Bratislava 3 ZP Sport Podbrezova 1 M13:30 | 07/05/22 | R 23 ZP Sport Podbrezova 0 FC Petrzalka U19 1 M12:00 | 24/04/22 | R 22 Trencin 5 ZP Sport Podbrezova 0 M12:00 | 09/04/22 | R 21 ZP Sport Podbrezova 1 FC Kosice 2 |
| 12 | |  Senica | 26 | 5 | 6 | 15 | 17 | 40 | -23 | 21 | M12:00 | 28/05/22 | R 26 MFk Dukla Banska Bystrica 1 Senica 0 G12:00 | 22/05/22 | R 25 Senica 3 FK Poprad U19 0 M14:30 | 11/05/22 | R 24 MSK Zilina 2 Senica 0 G12:00 | 08/05/22 | R 23 Senica 2 Ruzomberok 0 M17:00 | 05/05/22 | R 22 Slovan Bratislava 1 Senica 0 M12:00 | 10/04/22 | R 21 Senica 0 FC Petrzalka U19 1 |
| 13 | |  FK Poprad U19 | 26 | 4 | 4 | 18 | 20 | 79 | -59 | 16 | M12:00 | 28/05/22 | R 26 FK Poprad U19 1 Zemplin Michalovce 2 M12:00 | 22/05/22 | R 25 Senica 3 FK Poprad U19 0 G12:00 | 14/05/22 | R 24 FK Poprad U19 2 Nitra 1 B14:00 | 30/04/22 | R 23 FC Dac 1904 Dunajska Streda 1 FK Poprad U19 1 M12:00 | 23/04/22 | R 22 FK Poprad U19 0 Spartak Trnava 2 M12:00 | 08/04/22 | R 21 MFk Dukla Banska Bystrica 10 FK Poprad U19 0 |
| 14 | |  Nitra | 26 | 4 | 2 | 20 | 21 | 60 | -39 | 14 | M12:00 | 28/05/22 | R 26 Spartak Trnava 4 Nitra 0 M12:00 | 22/05/22 | R 25 Nitra 0 MFk Dukla Banska Bystrica 1 M12:00 | 14/05/22 | R 24 FK Poprad U19 2 Nitra 1 M12:00 | 30/04/22 | R 23 Nitra 1 MSK Zilina 2 M12:00 | 23/04/22 | R 22 Ruzomberok 2 Nitra 0 M17:00 | 07/04/22 | R 21 Nitra 0 Slovan Bratislava 3 |
