| 1 | |  Atletico Nacional Medellin | 18 | 10 | 4 | 4 | 37 | 15 | 22 | 34 | G23:30 | 18/04/21 | R 19  Atletico Nacional Medellin 7 Boyaca Patriotas FC 1 M04:00 | 11/04/21 | R 18 AD Cali 1 Atletico Nacional Medellin 0 G02:05 | 04/04/21 | R 17 Atletico Nacional Medellin 3 Envigado FC 0 M02:00 | 31/03/21 | R 16 CD Tolima 2 Atletico Nacional Medellin 1 |
| 2 | |  Independiente Santa Fe | 18 | 9 | 6 | 3 | 25 | 14 | 11 | 33 | G23:30 | 18/04/21 | R 19 CD La Equidad 1 Independiente Santa Fe 2 M04:00 | 12/04/21 | R 18 Independiente Santa Fe 1 Millonarios FC 2 G04:00 | 07/04/21 | R 17 CD Alianza Petrolera 0 Independiente Santa Fe 3 B03:40 | 03/04/21 | R 16 Independiente Santa Fe 1 Deportes Pereira 1 |
| 3 | |  Millonarios FC | 18 | 10 | 3 | 5 | 25 | 18 | 7 | 33 | |
| 4 | |  AD Cali | 18 | 8 | 7 | 3 | 19 | 14 | 5 | 31 | M23:30 | 18/04/21 | R 19 Millonarios FC 3 AD Cali 1 G04:00 | 11/04/21 | R 18 AD Cali 1 Atletico Nacional Medellin 0 G04:05 | 02/04/21 | R 16 CD La Equidad 2 AD Cali 5 B04:00 | 30/03/21 | R 15 AD Cali 1 AD Pasto 1 |
| 5 | |  CD Tolima | 18 | 8 | 6 | 4 | 22 | 14 | 8 | 30 | |
| 6 | |  CD La Equidad | 18 | 8 | 6 | 4 | 21 | 18 | 3 | 30 | M23:30 | 18/04/21 | R 19 CD La Equidad 1 Independiente Santa Fe 2 G23:30 | 04/04/21 | R 17 America de Cali 0 CD La Equidad 1 |
| 7 | |  CD Junior FC | 18 | 8 | 5 | 5 | 21 | 13 | 8 | 29 | B01:40 | 12/04/21 | R 18 AD Pasto 0 CD Junior FC 0 B04:00 | 05/04/21 | R 17 CD Junior FC 0 Rionegro Aguilas 0 |
| 8 | |  America de Cali | 18 | 7 | 8 | 3 | 19 | 12 | 7 | 29 | G23:30 | 18/04/21 | R 19 America de Cali 2 CD Tolima 0 B01:40 | 11/04/21 | R 18 Jaguares de Cordoba 0 America de Cali 0 M23:30 | 04/04/21 | R 17 America de Cali 0 CD La Equidad 1 G23:30 | 31/03/21 | R 16 America de Cali 2 Millonarios FC 1 |
| 9 | |  Independiente Medellin | 18 | 6 | 8 | 4 | 17 | 15 | 2 | 26 | M00:30 | 19/04/21 | R 19 CD Once Caldas 2 Independiente Medellin 0 B23:30 | 10/04/21 | R 18 Independiente Medellin 2 CD Alianza Petrolera 2 M02:00 | 07/04/21 | R 17 Deportes Pereira 1 Independiente Medellin 0 B04:10 | 28/03/21 | R 15 Independiente Medellin 0 Atletico Nacional Medellin 0 G23:15 | 24/03/21 | R 14 America de Cali 1 Independiente Medellin 2 B23:30 | 21/03/21 | R 13 Independiente Medellin 2 AD Pasto 2 |
| 10 | |  Jaguares de Cordoba | 18 | 7 | 4 | 7 | 21 | 21 | 0 | 25 | B23:30 | 18/04/21 | R 19 Boyaco Chico 0 Jaguares de Cordoba 0 B01:40 | 11/04/21 | R 18 Jaguares de Cordoba 0 America de Cali 0 G04:00 | 06/04/21 | R 17 CD Once Caldas 1 Jaguares de Cordoba 2 M04:05 | 31/03/21 | R 16 Jaguares de Cordoba 0 CD Junior FC 2 M04:00 | 25/03/21 | R 14 Atletico Nacional Medellin 3 Jaguares de Cordoba 1 M03:40 | 20/03/21 | R 13 Jaguares de Cordoba 0 Rionegro Aguilas 2 |
| 11 | |  CA Bucaramanga | 18 | 6 | 6 | 6 | 20 | 16 | 4 | 24 | G23:30 | 18/04/21 | R 19 CA Bucaramanga 4 Rionegro Aguilas 1 B03:40 | 16/04/21 | R 16 AD Pasto 1 CA Bucaramanga 1 B04:00 | 13/04/21 | R 18 CD Tolima 0 CA Bucaramanga 0 M02:00 | 06/04/21 | R 17 CA Bucaramanga 0 Boyaca Patriotas FC 1 M04:10 | 29/03/21 | R 15 Millonarios FC 2 CA Bucaramanga 1 G02:05 | 26/03/21 | R 14 CA Bucaramanga 1 AD Cali 0 |
| 12 | |  AD Pasto | 18 | 4 | 11 | 3 | 19 | 20 | -1 | 23 | M23:30 | 18/04/21 | R 19 Deportes Pereira 4 AD Pasto 2 B03:40 | 16/04/21 | R 16 AD Pasto 1 CA Bucaramanga 1 B01:40 | 12/04/21 | R 18 AD Pasto 0 CD Junior FC 0 B01:40 | 05/04/21 | R 17 Boyaco Chico 0 AD Pasto 0 B04:00 | 30/03/21 | R 15 AD Cali 1 AD Pasto 1 G22:00 | 25/03/21 | R 14 AD Pasto 1 Boyaca Patriotas FC 0 |
| 13 | |  Boyaco Chico | 18 | 5 | 4 | 9 | 17 | 20 | -3 | 19 | B23:30 | 18/04/21 | R 19 Boyaco Chico 0 Jaguares de Cordoba 0 G23:30 | 11/04/21 | R 18 Rionegro Aguilas 0 Boyaco Chico 3 B01:40 | 05/04/21 | R 17 Boyaco Chico 0 AD Pasto 0 G02:00 | 02/04/21 | R 16 Boyaco Chico 2 CD Alianza Petrolera 0 M00:00 | 28/03/21 | R 15 CD Once Caldas 4 Boyaco Chico 2 G02:00 | 24/03/21 | R 14 Boyaco Chico 3 Envigado FC 0 |
| 14 | |  Deportes Pereira | 18 | 4 | 6 | 8 | 16 | 24 | -8 | 18 | G23:30 | 18/04/21 | R 19 Deportes Pereira 4 AD Pasto 2 G23:30 | 11/04/21 | R 18 Envigado FC 0 Deportes Pereira 1 G02:00 | 07/04/21 | R 17 Deportes Pereira 1 Independiente Medellin 0 B03:40 | 03/04/21 | R 16 Independiente Santa Fe 1 Deportes Pereira 1 B22:00 | 28/03/21 | R 15 Deportes Pereira 0 CD La Equidad 0 M01:40 | 21/03/21 | R 13 CD Junior FC 3 Deportes Pereira 0 |
| 15 | |  CD Once Caldas | 18 | 3 | 8 | 7 | 20 | 23 | -3 | 17 | G00:30 | 19/04/21 | R 19 CD Once Caldas 2 Independiente Medellin 0 B04:00 | 14/04/21 | R 18 Boyaca Patriotas FC 1 CD Once Caldas 1 M04:00 | 06/04/21 | R 17 CD Once Caldas 1 Jaguares de Cordoba 2 B04:00 | 01/04/21 | R 16 Rionegro Aguilas 2 CD Once Caldas 2 G00:00 | 28/03/21 | R 15 CD Once Caldas 4 Boyaco Chico 2 M04:00 | 24/03/21 | R 14 Independiente Santa Fe 2 CD Once Caldas 0 |
| 16 | |  Envigado FC | 18 | 3 | 8 | 7 | 15 | 23 | -8 | 17 | B03:40 | 17/04/21 | R 19 CD Alianza Petrolera 1 Envigado FC 1 M23:30 | 11/04/21 | R 18 Envigado FC 0 Deportes Pereira 1 M02:05 | 04/04/21 | R 17 Atletico Nacional Medellin 3 Envigado FC 0 G01:40 | 01/04/21 | R 16 Envigado FC 3 Boyaca Patriotas FC 0 B22:00 | 27/03/21 | R 15 Envigado FC 0 CD Tolima 0 M02:00 | 24/03/21 | R 14 Boyaco Chico 3 Envigado FC 0 |
| 17 | |  Boyaca Patriotas FC | 18 | 5 | 2 | 11 | 17 | 31 | -14 | 17 | M23:30 | 18/04/21 | R 19 Atletico Nacional Medellin 7 Boyaca Patriotas FC 1 B04:00 | 14/04/21 | R 18 Boyaca Patriotas FC 1 CD Once Caldas 1 G02:00 | 06/04/21 | R 17 CA Bucaramanga 0 Boyaca Patriotas FC 1 M01:40 | 01/04/21 | R 16 Envigado FC 3 Boyaca Patriotas FC 0 G02:05 | 29/03/21 | R 15 Boyaca Patriotas FC 2 Rionegro Aguilas 1 M22:00 | 25/03/21 | R 14 AD Pasto 1 Boyaca Patriotas FC 0 |
| 18 | |  Rionegro Aguilas | 18 | 2 | 8 | 8 | 13 | 24 | -11 | 14 | M23:30 | 18/04/21 | R 19 CA Bucaramanga 4 Rionegro Aguilas 1 M23:30 | 11/04/21 | R 18 Rionegro Aguilas 0 Boyaco Chico 3 B04:00 | 05/04/21 | R 17 CD Junior FC 0 Rionegro Aguilas 0 B04:00 | 01/04/21 | R 16 Rionegro Aguilas 2 CD Once Caldas 2 M02:05 | 29/03/21 | R 15 Boyaca Patriotas FC 2 Rionegro Aguilas 1 B04:10 | 26/03/21 | R 14 Rionegro Aguilas 0 Millonarios FC 0 |
| 19 | |  CD Alianza Petrolera | 18 | 0 | 6 | 12 | 10 | 39 | -29 | 6 | B03:40 | 17/04/21 | R 19 CD Alianza Petrolera 1 Envigado FC 1 B23:30 | 10/04/21 | R 18 Independiente Medellin 2 CD Alianza Petrolera 2 M04:00 | 07/04/21 | R 17 CD Alianza Petrolera 0 Independiente Santa Fe 3 M02:00 | 02/04/21 | R 16 Boyaco Chico 2 CD Alianza Petrolera 0 M00:00 | 29/03/21 | R 15 CD Alianza Petrolera 0 America de Cali 2 B00:00 | 26/03/21 | R 14 CD La Equidad 1 CD Alianza Petrolera 1 |
