| 1 | |  Wigan | 46 | 27 | 11 | 8 | 82 | 44 | 38 | 92 | G14:30 | 30/04/22 | R 46  Shrewsbury Town 0 Wigan 3 M21:45 | 26/04/22 | R 27 Portsmouth 3 Wigan 2 B17:00 | 23/04/22 | R 45 Wigan 1 Plymouth Argyle 1 B21:45 | 19/04/22 | R 44 Ipswich Town 2 Wigan 2 M19:15 | 16/04/22 | R 43 Wigan 1 Cambridge United 2 B21:45 | 12/04/22 | R 40 Burton Albion 0 Wigan 0 |
| 2 | |  Rotherham United | 46 | 27 | 9 | 10 | 70 | 33 | 37 | 90 | G14:30 | 30/04/22 | R 46 Gillingham FC 0 Rotherham United 2 B21:45 | 26/04/22 | R 40 Sunderland 1 Rotherham United 1 G17:00 | 23/04/22 | R 45 Rotherham United 2 Oxford United 1 M21:45 | 19/04/22 | R 44 Burton Albion 2 Rotherham United 0 G14:30 | 16/04/22 | R 43 Rotherham United 1 Ipswich Town 0 M21:45 | 12/04/22 | R 41 Portsmouth 3 Rotherham United 0 |
| 3 | |  Milton Keynes Dons | 46 | 26 | 11 | 9 | 78 | 44 | 34 | 89 | G14:30 | 30/04/22 | R 46 Plymouth Argyle 0 Milton Keynes Dons 5 G17:00 | 23/04/22 | R 45 Milton Keynes Dons 2 Morecambe FC 0 M21:45 | 19/04/22 | R 44 Oxford United 1 Milton Keynes Dons 0 M21:45 | 16/04/22 | R 43 Milton Keynes Dons 2 Sheffield Wednesday 3 |
| 4 | |  Sheffield Wednesday | 46 | 24 | 13 | 9 | 78 | 50 | 28 | 85 | G14:30 | 30/04/22 | R 46 Sheffield Wednesday 4 Portsmouth 1 G21:45 | 26/04/22 | R 35 Fleetwood Town 2 Sheffield Wednesday 3 M17:00 | 23/04/22 | R 45 Wycombe Wanderers 1 Sheffield Wednesday 0 G21:45 | 19/04/22 | R 44 Sheffield Wednesday 1 Crewe Alexandra 0 |
| 5 | |  Sunderland | 46 | 24 | 12 | 10 | 79 | 53 | 26 | 84 | G14:30 | 30/04/22 | R 46 Morecambe FC 0 Sunderland 1 B21:45 | 26/04/22 | R 40 Sunderland 1 Rotherham United 1 G17:00 | 23/04/22 | R 45 Sunderland 5 Cambridge United 1 B17:00 | 18/04/22 | R 44 Plymouth Argyle 0 Sunderland 0 |
| 6 | |  Wycombe Wanderers | 46 | 23 | 14 | 9 | 75 | 51 | 24 | 83 | G14:30 | 30/04/22 | R 46 Burton Albion 1 Wycombe Wanderers 2 G17:00 | 23/04/22 | R 45 Wycombe Wanderers 1 Sheffield Wednesday 0 B17:00 | 18/04/22 | R 44 Wimbledon 1 Wycombe Wanderers 1 G17:00 | 15/04/22 | R 43 Wycombe Wanderers 2 Plymouth Argyle 0 |
| 7 | |  Plymouth Argyle | 46 | 23 | 11 | 12 | 68 | 48 | 20 | 80 | M14:30 | 30/04/22 | R 46 Plymouth Argyle 0 Milton Keynes Dons 5 B17:00 | 23/04/22 | R 45 Wigan 1 Plymouth Argyle 1 B17:00 | 18/04/22 | R 44 Plymouth Argyle 0 Sunderland 0 M17:00 | 15/04/22 | R 43 Wycombe Wanderers 2 Plymouth Argyle 0 B17:00 | 09/04/22 | R 42 Burton Albion 0 Plymouth Argyle 0 G17:00 | 02/04/22 | R 41 Plymouth Argyle 1 Oxford United 0 |
| 8 | |  Oxford United | 46 | 22 | 10 | 14 | 82 | 59 | 23 | 76 | B14:30 | 30/04/22 | R 46 Oxford United 1 Doncaster Rovers 1 M17:00 | 23/04/22 | R 45 Rotherham United 2 Oxford United 1 G21:45 | 19/04/22 | R 44 Oxford United 1 Milton Keynes Dons 0 G17:00 | 15/04/22 | R 43 Fleetwood Town 2 Oxford United 3 M17:00 | 09/04/22 | R 42 Oxford United 1 Sunderland 2 M21:45 | 05/04/22 | R 40 Morecambe FC 2 Oxford United 1 |
| 9 | |  Bolton Wanderers | 46 | 21 | 10 | 15 | 74 | 57 | 17 | 73 | G14:30 | 30/04/22 | R 46 Bolton Wanderers 4 Fleetwood Town 2 G17:00 | 23/04/22 | R 45 Cheltenham Town 1 Bolton Wanderers 2 G17:00 | 18/04/22 | R 44 Bolton Wanderers 3 Accrington Stanley 1 G17:00 | 15/04/22 | R 43 Doncaster Rovers 1 Bolton Wanderers 2 B17:00 | 09/04/22 | R 42 Bolton Wanderers 1 Sheffield Wednesday 1 B22:00 | 05/04/22 | R 40 Bolton Wanderers 1 Portsmouth 1 |
| 10 | |  Portsmouth | 46 | 20 | 13 | 13 | 68 | 51 | 17 | 73 | M14:30 | 30/04/22 | R 46 Sheffield Wednesday 4 Portsmouth 1 G21:45 | 26/04/22 | R 27 Portsmouth 3 Wigan 2 G17:00 | 23/04/22 | R 45 Portsmouth 3 Gillingham FC 1 B17:00 | 18/04/22 | R 44 Morecambe FC 1 Portsmouth 1 G17:00 | 15/04/22 | R 43 Portsmouth 3 Lincoln City 2 G21:45 | 12/04/22 | R 41 Portsmouth 3 Rotherham United 0 |
| 11 | |  Ipswich Town | 46 | 18 | 16 | 12 | 67 | 46 | 21 | 70 | G14:30 | 30/04/22 | R 46 Ipswich Town 4 Charlton Athletic 0 B17:00 | 23/04/22 | R 45 Crewe Alexandra 1 Ipswich Town 1 B21:45 | 19/04/22 | R 44 Ipswich Town 2 Wigan 2 M14:30 | 16/04/22 | R 43 Rotherham United 1 Ipswich Town 0 B17:00 | 09/04/22 | R 42 Shrewsbury Town 1 Ipswich Town 1 M17:00 | 02/04/22 | R 41 Ipswich Town 0 Cambridge United 1 |
| 12 | |  Accrington Stanley | 46 | 17 | 10 | 19 | 61 | 80 | -19 | 61 | G14:30 | 30/04/22 | R 46 Wimbledon 3 Accrington Stanley 4 G17:00 | 23/04/22 | R 45 Accrington Stanley 2 Lincoln City 1 M17:00 | 18/04/22 | R 44 Bolton Wanderers 3 Accrington Stanley 1 B17:00 | 15/04/22 | R 43 Accrington Stanley 0 Burton Albion 0 G17:00 | 09/04/22 | R 42 Fleetwood Town 1 Accrington Stanley 2 M21:45 | 05/04/22 | R 26 Wigan 3 Accrington Stanley 0 |
| 13 | |  Charlton Athletic | 46 | 17 | 8 | 21 | 55 | 59 | -4 | 59 | M14:30 | 30/04/22 | R 46 Ipswich Town 4 Charlton Athletic 0 G17:00 | 23/04/22 | R 45 Charlton Athletic 2 Shrewsbury Town 0 G21:45 | 19/04/22 | R 44 Cambridge United 0 Charlton Athletic 2 M17:00 | 15/04/22 | R 43 Charlton Athletic 2 Morecambe FC 3 G17:00 | 09/04/22 | R 42 Rotherham United 0 Charlton Athletic 1 B21:45 | 05/04/22 | R 24 Wimbledon 1 Charlton Athletic 1 |
| 14 | |  Cambridge United | 46 | 15 | 13 | 18 | 56 | 74 | -18 | 58 | B14:30 | 30/04/22 | R 46 Cambridge United 2 Cheltenham Town 2 M17:00 | 23/04/22 | R 45 Sunderland 5 Cambridge United 1 M21:45 | 19/04/22 | R 44 Cambridge United 0 Charlton Athletic 2 G19:15 | 16/04/22 | R 43 Wigan 1 Cambridge United 2 G17:00 | 09/04/22 | R 42 Cambridge United 2 Morecambe FC 1 M21:45 | 05/04/22 | R 31 Cambridge United 1 Wycombe Wanderers 4 |
| 15 | |  Cheltenham Town | 46 | 13 | 17 | 16 | 66 | 80 | -14 | 56 | B14:30 | 30/04/22 | R 46 Cambridge United 2 Cheltenham Town 2 M17:00 | 23/04/22 | R 45 Cheltenham Town 1 Bolton Wanderers 2 M17:00 | 18/04/22 | R 44 Lincoln City 3 Cheltenham Town 0 B17:00 | 15/04/22 | R 43 Cheltenham Town 2 Gillingham FC 2 G17:00 | 09/04/22 | R 42 Cheltenham Town 1 Portsmouth 0 B17:00 | 02/04/22 | R 41 Accrington Stanley 4 Cheltenham Town 4 |
| 16 | |  Burton Albion | 46 | 14 | 11 | 21 | 51 | 67 | -16 | 53 | M14:30 | 30/04/22 | R 46 Burton Albion 1 Wycombe Wanderers 2 M17:00 | 23/04/22 | R 45 Doncaster Rovers 2 Burton Albion 0 G21:45 | 19/04/22 | R 44 Burton Albion 2 Rotherham United 0 B17:00 | 15/04/22 | R 43 Accrington Stanley 0 Burton Albion 0 B21:45 | 12/04/22 | R 40 Burton Albion 0 Wigan 0 B17:00 | 09/04/22 | R 42 Burton Albion 0 Plymouth Argyle 0 |
| 17 | |  Lincoln City | 46 | 14 | 10 | 22 | 55 | 63 | -8 | 52 | G14:30 | 30/04/22 | R 46 Lincoln City 2 Crewe Alexandra 1 M17:00 | 23/04/22 | R 45 Accrington Stanley 2 Lincoln City 1 G17:00 | 18/04/22 | R 44 Lincoln City 3 Cheltenham Town 0 M17:00 | 15/04/22 | R 43 Portsmouth 3 Lincoln City 2 M17:00 | 09/04/22 | R 42 Lincoln City 1 Wigan 3 B21:45 | 05/04/22 | R 34 Fleetwood Town 1 Lincoln City 1 |
| 18 | |  Shrewsbury Town | 46 | 12 | 14 | 20 | 47 | 51 | -4 | 50 | M14:30 | 30/04/22 | R 46 Shrewsbury Town 0 Wigan 3 M17:00 | 23/04/22 | R 45 Charlton Athletic 2 Shrewsbury Town 0 B17:00 | 18/04/22 | R 44 Shrewsbury Town 3 Doncaster Rovers 3 M17:00 | 15/04/22 | R 43 Sunderland 3 Shrewsbury Town 2 B17:00 | 09/04/22 | R 42 Shrewsbury Town 1 Ipswich Town 1 M17:00 | 02/04/22 | R 41 Milton Keynes Dons 2 Shrewsbury Town 0 |
| 19 | |  Morecambe FC | 46 | 10 | 12 | 24 | 57 | 88 | -31 | 42 | M14:30 | 30/04/22 | R 46 Morecambe FC 0 Sunderland 1 M17:00 | 23/04/22 | R 45 Milton Keynes Dons 2 Morecambe FC 0 B17:00 | 18/04/22 | R 44 Morecambe FC 1 Portsmouth 1 G17:00 | 15/04/22 | R 43 Charlton Athletic 2 Morecambe FC 3 M17:00 | 09/04/22 | R 42 Cambridge United 2 Morecambe FC 1 G21:45 | 05/04/22 | R 40 Morecambe FC 2 Oxford United 1 |
| 20 | |  Fleetwood Town | 46 | 8 | 16 | 22 | 62 | 82 | -20 | 40 | M14:30 | 30/04/22 | R 46 Bolton Wanderers 4 Fleetwood Town 2 M21:45 | 26/04/22 | R 35 Fleetwood Town 2 Sheffield Wednesday 3 B17:00 | 23/04/22 | R 45 Fleetwood Town 1 Wimbledon 1 B17:00 | 18/04/22 | R 44 Gillingham FC 0 Fleetwood Town 0 M17:00 | 15/04/22 | R 43 Fleetwood Town 2 Oxford United 3 M17:00 | 09/04/22 | R 42 Fleetwood Town 1 Accrington Stanley 2 |
| 21 | |  Gillingham FC | 46 | 8 | 16 | 22 | 35 | 69 | -34 | 40 | M14:30 | 30/04/22 | R 46 Gillingham FC 0 Rotherham United 2 M17:00 | 23/04/22 | R 45 Portsmouth 3 Gillingham FC 1 B17:00 | 18/04/22 | R 44 Gillingham FC 0 Fleetwood Town 0 B17:00 | 15/04/22 | R 43 Cheltenham Town 2 Gillingham FC 2 B17:00 | 09/04/22 | R 42 Gillingham FC 1 Wycombe Wanderers 1 M17:00 | 02/04/22 | R 41 Sunderland 1 Gillingham FC 0 |
| 22 | |  Doncaster Rovers | 46 | 10 | 8 | 28 | 37 | 82 | -45 | 38 | B14:30 | 30/04/22 | R 46 Oxford United 1 Doncaster Rovers 1 G17:00 | 23/04/22 | R 45 Doncaster Rovers 2 Burton Albion 0 B17:00 | 18/04/22 | R 44 Shrewsbury Town 3 Doncaster Rovers 3 M17:00 | 15/04/22 | R 43 Doncaster Rovers 1 Bolton Wanderers 2 G17:00 | 09/04/22 | R 42 Doncaster Rovers 2 Crewe Alexandra 0 M17:00 | 02/04/22 | R 41 Wycombe Wanderers 2 Doncaster Rovers 0 |
| 23 | |  Wimbledon | 46 | 6 | 19 | 21 | 49 | 75 | -26 | 37 | M14:30 | 30/04/22 | R 46 Wimbledon 3 Accrington Stanley 4 B17:00 | 23/04/22 | R 45 Fleetwood Town 1 Wimbledon 1 B17:00 | 18/04/22 | R 44 Wimbledon 1 Wycombe Wanderers 1 M17:00 | 15/04/22 | R 43 Crewe Alexandra 3 Wimbledon 1 B17:00 | 09/04/22 | R 42 Wimbledon 1 Milton Keynes Dons 1 B21:45 | 05/04/22 | R 24 Wimbledon 1 Charlton Athletic 1 |
| 24 | |  Crewe Alexandra | 46 | 7 | 8 | 31 | 37 | 83 | -46 | 29 | M14:30 | 30/04/22 | R 46 Lincoln City 2 Crewe Alexandra 1 B17:00 | 23/04/22 | R 45 Crewe Alexandra 1 Ipswich Town 1 M21:45 | 19/04/22 | R 44 Sheffield Wednesday 1 Crewe Alexandra 0 G17:00 | 15/04/22 | R 43 Crewe Alexandra 3 Wimbledon 1 M17:00 | 09/04/22 | R 42 Doncaster Rovers 2 Crewe Alexandra 0 M21:45 | 05/04/22 | R 40 Milton Keynes Dons 2 Crewe Alexandra 1 |
