| 1 | |  Rio Ave FC | 34 | 21 | 7 | 6 | 52 | 31 | 21 | 70 | G13:00 | 15/05/22 | R 34  Rio Ave FC 3 GD Chaves 0 G16:00 | 07/05/22 | R 33 SC Covilha 0 Rio Ave FC 1 G16:00 | 01/05/22 | R 32 Rio Ave FC 1 Casa Pia Lisbon 0 B16:00 | 24/04/22 | R 31 CD Mafra 1 Rio Ave FC 1 G17:30 | 17/04/22 | R 30 Rio Ave FC 2 SL Benfica B 1 M16:00 | 10/04/22 | R 29 Nacional de Madeira 2 Rio Ave FC 0 |
| 2 | |  Casa Pia Lisbon | 34 | 21 | 5 | 8 | 50 | 22 | 28 | 68 | G13:00 | 15/05/22 | R 34 Leixoes 1 Casa Pia Lisbon 5 G17:30 | 07/05/22 | R 33 Casa Pia Lisbon 2 UD Vilafranquense 1 M16:00 | 01/05/22 | R 32 Rio Ave FC 1 Casa Pia Lisbon 0 G13:00 | 23/04/22 | R 31 Casa Pia Lisbon 3 Estrela Amadora 0 M16:00 | 15/04/22 | R 30 Varzim SC 1 Casa Pia Lisbon 0 G13:00 | 09/04/22 | R 29 Casa Pia Lisbon 1 SC Farense 0 |
| 3 | |  GD Chaves | 34 | 18 | 10 | 6 | 54 | 35 | 19 | 64 | M13:00 | 15/05/22 | R 34 Rio Ave FC 3 GD Chaves 0 B13:00 | 08/05/22 | R 33 GD Chaves 2 Estrela Amadora 2 G13:00 | 30/04/22 | R 32 SC Farense 1 GD Chaves 2 G16:00 | 23/04/22 | R 31 GD Chaves 3 Academica de Coimbra 2 G13:00 | 15/04/22 | R 30 GD Chaves 1 SC Covilha 0 G16:00 | 09/04/22 | R 29 CD Mafra 0 GD Chaves 1 |
| 4 | |  CD Feirense | 34 | 17 | 7 | 10 | 50 | 37 | 13 | 58 | G17:00 | 15/05/22 | R 34 CD Feirense 4 Nacional de Madeira 1 G16:00 | 07/05/22 | R 33 SL Benfica B 1 CD Feirense 2 M14:45 | 01/05/22 | R 32 CD Feirense 1 CD Trofense 2 M13:00 | 24/04/22 | R 31 FC Penafiel 2 CD Feirense 0 B21:00 | 16/04/22 | R 30 CD Feirense 1 UD Vilafranquense 1 M17:30 | 10/04/22 | R 29 FC Porto B 2 CD Feirense 1 |
| 5 | |  SL Benfica B | 34 | 17 | 6 | 11 | 61 | 44 | 17 | 57 | G17:30 | 13/05/22 | R 34 FC Porto B 2 SL Benfica B 3 M16:00 | 07/05/22 | R 33 SL Benfica B 1 CD Feirense 2 G13:00 | 01/05/22 | R 32 UD Vilafranquense 1 SL Benfica B 2 M17:30 | 24/04/22 | R 31 SL Benfica B 1 Academico de Viseu FC 2 M17:30 | 17/04/22 | R 30 Rio Ave FC 2 SL Benfica B 1 B16:00 | 09/04/22 | R 29 SL Benfica B 0 Estrela Amadora 0 |
| 6 | |  Nacional de Madeira | 34 | 14 | 9 | 11 | 52 | 44 | 8 | 51 | M17:00 | 15/05/22 | R 34 CD Feirense 4 Nacional de Madeira 1 M17:30 | 07/05/22 | R 33 Nacional de Madeira 1 Academico de Viseu FC 2 G17:30 | 30/04/22 | R 32 Leixoes 0 Nacional de Madeira 1 G17:30 | 24/04/22 | R 31 Nacional de Madeira 3 SC Farense 2 B19:00 | 16/04/22 | R 30 Estrela Amadora 0 Nacional de Madeira 0 G16:00 | 10/04/22 | R 29 Nacional de Madeira 2 Rio Ave FC 0 |
| 7 | |  FC Penafiel | 34 | 14 | 9 | 11 | 38 | 38 | 0 | 51 | G20:00 | 13/05/22 | R 34 Academico de Viseu FC 1 FC Penafiel 2 M13:00 | 07/05/22 | R 33 FC Penafiel 1 FC Porto B 2 G16:00 | 30/04/22 | R 32 Estrela Amadora 0 FC Penafiel 2 G13:00 | 24/04/22 | R 31 FC Penafiel 2 CD Feirense 0 B13:00 | 16/04/22 | R 30 Academica de Coimbra 0 FC Penafiel 0 G20:00 | 08/04/22 | R 29 FC Penafiel 4 Varzim SC 1 |
| 8 | |  Leixoes | 34 | 13 | 9 | 12 | 42 | 40 | 2 | 48 | M13:00 | 15/05/22 | R 34 Leixoes 1 Casa Pia Lisbon 5 G13:00 | 07/05/22 | R 33 CD Mafra 0 Leixoes 2 M17:30 | 30/04/22 | R 32 Leixoes 0 Nacional de Madeira 1 B19:00 | 24/04/22 | R 31 SC Covilha 1 Leixoes 1 B16:00 | 16/04/22 | R 30 Leixoes 0 FC Porto B 0 G19:00 | 10/04/22 | R 29 CD Trofense 1 Leixoes 2 |
| 9 | |  CD Mafra | 34 | 11 | 10 | 13 | 37 | 42 | -5 | 43 | M17:30 | 15/05/22 | R 34 Varzim SC 2 CD Mafra 0 M13:00 | 07/05/22 | R 33 CD Mafra 0 Leixoes 2 G13:00 | 30/04/22 | R 32 Academica de Coimbra 0 CD Mafra 2 B16:00 | 24/04/22 | R 31 CD Mafra 1 Rio Ave FC 1 M13:00 | 16/04/22 | R 30 SC Farense 1 CD Mafra 0 M16:00 | 09/04/22 | R 29 CD Mafra 0 GD Chaves 1 |
| 10 | |  FC Porto B | 34 | 10 | 12 | 12 | 45 | 49 | -4 | 42 | M17:30 | 13/05/22 | R 34 FC Porto B 2 SL Benfica B 3 G13:00 | 07/05/22 | R 33 FC Penafiel 1 FC Porto B 2 B20:00 | 29/04/22 | R 32 Academico de Viseu FC 1 FC Porto B 1 M17:30 | 24/04/22 | R 31 FC Porto B 0 UD Vilafranquense 1 B16:00 | 16/04/22 | R 30 Leixoes 0 FC Porto B 0 G17:30 | 10/04/22 | R 29 FC Porto B 2 CD Feirense 1 |
| 11 | |  SC Farense | 34 | 10 | 11 | 13 | 40 | 42 | -2 | 41 | B13:00 | 14/05/22 | R 34 Academica de Coimbra 0 SC Farense 0 M16:00 | 08/05/22 | R 33 SC Farense 0 Varzim SC 1 M13:00 | 30/04/22 | R 32 SC Farense 1 GD Chaves 2 M17:30 | 24/04/22 | R 31 Nacional de Madeira 3 SC Farense 2 G13:00 | 16/04/22 | R 30 SC Farense 1 CD Mafra 0 M13:00 | 09/04/22 | R 29 Casa Pia Lisbon 1 SC Farense 0 |
| 12 | |  UD Vilafranquense | 34 | 10 | 11 | 13 | 41 | 47 | -6 | 41 | M17:30 | 14/05/22 | R 34 UD Vilafranquense 2 CD Trofense 4 M17:30 | 07/05/22 | R 33 Casa Pia Lisbon 2 UD Vilafranquense 1 M13:00 | 01/05/22 | R 32 UD Vilafranquense 1 SL Benfica B 2 G17:30 | 24/04/22 | R 31 FC Porto B 0 UD Vilafranquense 1 B21:00 | 16/04/22 | R 30 CD Feirense 1 UD Vilafranquense 1 G17:30 | 09/04/22 | R 29 UD Vilafranquense 2 Academico de Viseu FC 1 |
| 13 | |  CD Trofense | 34 | 10 | 10 | 14 | 35 | 41 | -6 | 40 | G17:30 | 14/05/22 | R 34 UD Vilafranquense 2 CD Trofense 4 G20:00 | 08/05/22 | R 33 CD Trofense 2 Academica de Coimbra 1 G14:45 | 01/05/22 | R 32 CD Feirense 1 CD Trofense 2 G17:30 | 25/04/22 | R 31 CD Trofense 1 Varzim SC 0 M17:30 | 16/04/22 | R 30 Academico de Viseu FC 2 CD Trofense 1 M19:00 | 10/04/22 | R 29 CD Trofense 1 Leixoes 2 |
| 14 | |  Estrela Amadora | 34 | 9 | 10 | 15 | 42 | 55 | -13 | 37 | M17:30 | 15/05/22 | R 34 Estrela Amadora 0 SC Covilha 1 B13:00 | 08/05/22 | R 33 GD Chaves 2 Estrela Amadora 2 M16:00 | 30/04/22 | R 32 Estrela Amadora 0 FC Penafiel 2 M13:00 | 23/04/22 | R 31 Casa Pia Lisbon 3 Estrela Amadora 0 B19:00 | 16/04/22 | R 30 Estrela Amadora 0 Nacional de Madeira 0 B16:00 | 09/04/22 | R 29 SL Benfica B 0 Estrela Amadora 0 |
| 15 | |  Academico de Viseu FC | 34 | 10 | 7 | 17 | 31 | 49 | -18 | 37 | M20:00 | 13/05/22 | R 34 Academico de Viseu FC 1 FC Penafiel 2 G17:30 | 07/05/22 | R 33 Nacional de Madeira 1 Academico de Viseu FC 2 B20:00 | 29/04/22 | R 32 Academico de Viseu FC 1 FC Porto B 1 G17:30 | 24/04/22 | R 31 SL Benfica B 1 Academico de Viseu FC 2 G17:30 | 16/04/22 | R 30 Academico de Viseu FC 2 CD Trofense 1 M17:30 | 09/04/22 | R 29 UD Vilafranquense 2 Academico de Viseu FC 1 |
| 16 | |  SC Covilha | 34 | 8 | 12 | 14 | 30 | 43 | -13 | 36 | G17:30 | 15/05/22 | R 34 Estrela Amadora 0 SC Covilha 1 M16:00 | 07/05/22 | R 33 SC Covilha 0 Rio Ave FC 1 G21:15 | 30/04/22 | R 32 Varzim SC 0 SC Covilha 2 B19:00 | 24/04/22 | R 31 SC Covilha 1 Leixoes 1 M13:00 | 15/04/22 | R 30 GD Chaves 1 SC Covilha 0 |
| 17 | |  Varzim SC | 34 | 8 | 11 | 15 | 25 | 39 | -14 | 35 | G17:30 | 15/05/22 | R 34 Varzim SC 2 CD Mafra 0 G16:00 | 08/05/22 | R 33 SC Farense 0 Varzim SC 1 M21:15 | 30/04/22 | R 32 Varzim SC 0 SC Covilha 2 M17:30 | 25/04/22 | R 31 CD Trofense 1 Varzim SC 0 G16:00 | 15/04/22 | R 30 Varzim SC 1 Casa Pia Lisbon 0 M20:00 | 08/04/22 | R 29 FC Penafiel 4 Varzim SC 1 |
| 18 | |  Academica de Coimbra | 34 | 3 | 8 | 23 | 35 | 62 | -27 | 17 | B13:00 | 14/05/22 | R 34 Academica de Coimbra 0 SC Farense 0 M20:00 | 08/05/22 | R 33 CD Trofense 2 Academica de Coimbra 1 M13:00 | 30/04/22 | R 32 Academica de Coimbra 0 CD Mafra 2 M16:00 | 23/04/22 | R 31 GD Chaves 3 Academica de Coimbra 2 B13:00 | 16/04/22 | R 30 Academica de Coimbra 0 FC Penafiel 0 M13:00 | 10/04/22 | R 29 SC Covilha 2 Academica de Coimbra 0 |
