| 1 | |  FC Dinamo Kiev | 26 | 22 | 3 | 1 | 96 | 20 | 76 | 69 | G13:00 | 08/05/21 | R 26  Kolos Kovalivka 1 FC Dinamo Kiev 4 G12:00 | 04/05/21 | R 25 FC Dinamo Kiev 2 FC Mariupol 1 G12:00 | 30/04/21 | R 24 Vorskla Poltava 2 FC Dinamo Kiev 4 G13:00 | 24/04/21 | R 23 FC Dinamo Kiev 2 FC Ingulets U21 1 G12:00 | 20/04/21 | R 16 FC Lviv 2 FC Dinamo Kiev 4 G12:00 | 16/04/21 | R 22 Shakhtar Donetsk 0 FC Dinamo Kiev 2 |
| 2 | |  Shakhtar Donetsk | 25 | 19 | 2 | 4 | 69 | 22 | 47 | 59 | G11:00 | 08/05/21 | R 26 Shakhtar Donetsk 3 FC Ingulets U21 1 G15:00 | 05/05/21 | R 25 FC Minaj U21 0 Shakhtar Donetsk 1 B12:00 | 30/04/21 | R 24 Shakhtar Donetsk 1 SC Dnipro-1 1 G13:00 | 24/04/21 | R 23 FC Oleksandriya 0 Shakhtar Donetsk 2 M12:00 | 16/04/21 | R 22 Shakhtar Donetsk 0 FC Dinamo Kiev 2 B12:00 | 09/04/21 | R 21 FC Mariupol 1 Shakhtar Donetsk 1 |
| 3 | |  FC Rukh LVIV U21 | 26 | 15 | 7 | 4 | 60 | 30 | 30 | 52 | B12:00 | 08/05/21 | R 26 SC Dnipro-1 0 FC Rukh LVIV U21 0 G16:00 | 05/05/21 | R 25 FC Rukh LVIV U21 4 Olimpik Donetsk 1 B11:30 | 30/04/21 | R 24 FC Rukh LVIV U21 3 FC Oleksandriya 3 B14:00 | 23/04/21 | R 23 FC Mariupol 3 FC Rukh LVIV U21 3 M12:00 | 20/04/21 | R 1 Vorskla Poltava 3 FC Rukh LVIV U21 1 G14:00 | 17/04/21 | R 22 FC Ingulets U21 1 FC Rukh LVIV U21 5 |
| 4 | |  FC Oleksandriya | 25 | 14 | 5 | 6 | 49 | 31 | 18 | 47 | G15:00 | 08/05/21 | R 26 Zorya Lugansk 1 FC Oleksandriya 6 G13:00 | 04/05/21 | R 25 FC Oleksandriya 4 Kolos Kovalivka 1 B11:30 | 30/04/21 | R 24 FC Rukh LVIV U21 3 FC Oleksandriya 3 M13:00 | 24/04/21 | R 23 FC Oleksandriya 0 Shakhtar Donetsk 2 G12:00 | 15/04/21 | R 22 FC Lviv 0 FC Oleksandriya 2 G12:00 | 09/04/21 | R 21 FC Desna Chernihiv 0 FC Oleksandriya 1 |
| 5 | |  Vorskla Poltava | 26 | 13 | 4 | 9 | 56 | 39 | 17 | 43 | G15:00 | 08/05/21 | R 26 FC Minaj U21 1 Vorskla Poltava 2 G12:00 | 04/05/21 | R 25 Vorskla Poltava 3 FC Desna Chernihiv 1 M12:00 | 30/04/21 | R 24 Vorskla Poltava 2 FC Dinamo Kiev 4 M13:00 | 23/04/21 | R 23 Kolos Kovalivka 3 Vorskla Poltava 0 G12:00 | 20/04/21 | R 1 Vorskla Poltava 3 FC Rukh LVIV U21 1 G14:00 | 16/04/21 | R 22 Vorskla Poltava 2 Zorya Lugansk 1 |
| 6 | |  SC Dnipro-1 | 26 | 12 | 6 | 8 | 54 | 43 | 11 | 42 | B12:00 | 08/05/21 | R 26 SC Dnipro-1 0 FC Rukh LVIV U21 0 G12:00 | 04/05/21 | R 25 SC Dnipro-1 4 Zorya Lugansk 2 B12:00 | 30/04/21 | R 24 Shakhtar Donetsk 1 SC Dnipro-1 1 G13:30 | 23/04/21 | R 23 SC Dnipro-1 4 FC Minaj U21 1 M11:00 | 17/04/21 | R 22 Kolos Kovalivka 6 SC Dnipro-1 4 M13:00 | 09/04/21 | R 21 FC Dinamo Kiev 3 SC Dnipro-1 0 |
| 7 | |  Kolos Kovalivka | 26 | 12 | 4 | 10 | 62 | 47 | 15 | 40 | M13:00 | 08/05/21 | R 26 Kolos Kovalivka 1 FC Dinamo Kiev 4 M13:00 | 04/05/21 | R 25 FC Oleksandriya 4 Kolos Kovalivka 1 G11:00 | 30/04/21 | R 24 FC Desna Chernihiv 0 Kolos Kovalivka 5 G13:00 | 23/04/21 | R 23 Kolos Kovalivka 3 Vorskla Poltava 0 G11:00 | 17/04/21 | R 22 Kolos Kovalivka 6 SC Dnipro-1 4 G17:00 | 10/04/21 | R 21 Olimpik Donetsk 0 Kolos Kovalivka 3 |
| 8 | |  FC Mariupol | 24 | 10 | 6 | 8 | 42 | 37 | 5 | 36 | G13:00 | 08/05/21 | R 26 FC Mariupol 5 FC Desna Chernihiv 0 M12:00 | 04/05/21 | R 25 FC Dinamo Kiev 2 FC Mariupol 1 G11:00 | 29/04/21 | R 24 FC Mariupol 3 FC Lviv 1 B14:00 | 23/04/21 | R 23 FC Mariupol 3 FC Rukh LVIV U21 3 G12:00 | 17/04/21 | R 22 FC Mariupol 1 Olimpik Donetsk 0 B12:00 | 09/04/21 | R 21 FC Mariupol 1 Shakhtar Donetsk 1 |
| 9 | |  Zorya Lugansk | 25 | 10 | 4 | 11 | 49 | 51 | -2 | 34 | M15:00 | 08/05/21 | R 26 Zorya Lugansk 1 FC Oleksandriya 6 M12:00 | 04/05/21 | R 25 SC Dnipro-1 4 Zorya Lugansk 2 B15:00 | 01/05/21 | R 24 Zorya Lugansk 1 FC Minaj U21 1 G15:00 | 24/04/21 | R 23 Zorya Lugansk 4 Olimpik Donetsk 1 M14:00 | 16/04/21 | R 22 Vorskla Poltava 2 Zorya Lugansk 1 G14:00 | 10/04/21 | R 21 Zorya Lugansk 4 FC Ingulets U21 0 |
| 10 | |  FC Lviv | 25 | 7 | 3 | 15 | 39 | 49 | -10 | 24 | M11:00 | 08/05/21 | R 26 FC Lviv 0 Olimpik Donetsk 2 G14:00 | 05/05/21 | R 25 FC Ingulets U21 1 FC Lviv 3 M11:00 | 29/04/21 | R 24 FC Mariupol 3 FC Lviv 1 B12:00 | 23/04/21 | R 23 FC Lviv 2 FC Desna Chernihiv 2 M12:00 | 20/04/21 | R 16 FC Lviv 2 FC Dinamo Kiev 4 M12:00 | 15/04/21 | R 22 FC Lviv 0 FC Oleksandriya 2 |
| 11 | |  FC Minaj U21 | 25 | 5 | 4 | 16 | 21 | 54 | -33 | 19 | M15:00 | 08/05/21 | R 26 FC Minaj U21 1 Vorskla Poltava 2 M15:00 | 05/05/21 | R 25 FC Minaj U21 0 Shakhtar Donetsk 1 B15:00 | 01/05/21 | R 24 Zorya Lugansk 1 FC Minaj U21 1 M13:30 | 23/04/21 | R 23 SC Dnipro-1 4 FC Minaj U21 1 G11:00 | 16/04/21 | R 22 FC Minaj U21 2 FC Desna Chernihiv 0 M11:00 | 10/04/21 | R 21 FC Rukh LVIV U21 4 FC Minaj U21 0 |
| 12 | |  FC Desna Chernihiv | 26 | 3 | 5 | 18 | 23 | 76 | -53 | 14 | M13:00 | 08/05/21 | R 26 FC Mariupol 5 FC Desna Chernihiv 0 M12:00 | 04/05/21 | R 25 Vorskla Poltava 3 FC Desna Chernihiv 1 M11:00 | 30/04/21 | R 24 FC Desna Chernihiv 0 Kolos Kovalivka 5 B12:00 | 23/04/21 | R 23 FC Lviv 2 FC Desna Chernihiv 2 M11:00 | 16/04/21 | R 22 FC Minaj U21 2 FC Desna Chernihiv 0 M12:00 | 09/04/21 | R 21 FC Desna Chernihiv 0 FC Oleksandriya 1 |
| 13 | |  Olimpik Donetsk | 24 | 3 | 4 | 17 | 18 | 71 | -53 | 13 | G11:00 | 08/05/21 | R 26 FC Lviv 0 Olimpik Donetsk 2 M16:00 | 05/05/21 | R 25 FC Rukh LVIV U21 4 Olimpik Donetsk 1 G11:00 | 01/05/21 | R 24 Olimpik Donetsk 2 FC Ingulets U21 1 M15:00 | 24/04/21 | R 23 Zorya Lugansk 4 Olimpik Donetsk 1 M12:00 | 17/04/21 | R 22 FC Mariupol 1 Olimpik Donetsk 0 M17:00 | 10/04/21 | R 21 Olimpik Donetsk 0 Kolos Kovalivka 3 |
| 14 | |  FC Ingulets U21 | 25 | 3 | 1 | 21 | 18 | 86 | -68 | 10 | M11:00 | 08/05/21 | R 26 Shakhtar Donetsk 3 FC Ingulets U21 1 M14:00 | 05/05/21 | R 25 FC Ingulets U21 1 FC Lviv 3 M11:00 | 01/05/21 | R 24 Olimpik Donetsk 2 FC Ingulets U21 1 M13:00 | 24/04/21 | R 23 FC Dinamo Kiev 2 FC Ingulets U21 1 M14:00 | 17/04/21 | R 22 FC Ingulets U21 1 FC Rukh LVIV U21 5 M14:00 | 10/04/21 | R 21 Zorya Lugansk 4 FC Ingulets U21 0 |
