| 1 | |  Club Leon | 17 | 11 | 2 | 4 | 34 | 18 | 16 | 35 | G17:00 | 01/05/22 | R 17  Club Leon 3 Deportivo Toluca FC 1 G19:00 | 24/04/22 | R 16 Club Santos Laguna 0 Club Leon 3 |
| 2 | |  Pachuca | 17 | 10 | 3 | 4 | 31 | 17 | 14 | 33 | M17:00 | 01/05/22 | R 17 Pumas Unam 2 Pachuca 1 G17:30 | 23/04/22 | R 16 Pachuca 4 CF Monterrey 0 B17:30 | 19/04/22 | R 15 Pachuca 2 Puebla 2 G18:00 | 15/04/22 | R 14 FC Juarez 0 Pachuca 2 |
| 3 | |  Club America | 17 | 10 | 1 | 6 | 32 | 19 | 13 | 31 | |
| 4 | |  Club Tijuana de Caliente | 17 | 9 | 4 | 4 | 25 | 19 | 6 | 31 | M17:00 | 30/04/22 | R 17 CF Monterrey 3 Club Tijuana de Caliente 0 G01:45 | 25/04/22 | R 16 Club Tijuana de Caliente 1 Queretaro FC 0 |
| 5 | |  Chivas Guadalajara | 17 | 9 | 4 | 4 | 23 | 17 | 6 | 31 | G17:00 | 29/04/22 | R 17 Necaxa 0 Chivas Guadalajara 3 G17:00 | 23/04/22 | R 16 Chivas Guadalajara 3 Pumas Unam 1 B17:00 | 19/04/22 | R 15 Chivas Guadalajara 1 Club Tijuana de Caliente 1 M17:00 | 16/04/22 | R 14 Cruz Azul 2 Chivas Guadalajara 1 |
| 6 | |  Deportivo Toluca FC | 17 | 8 | 5 | 4 | 25 | 19 | 6 | 29 | M17:00 | 01/05/22 | R 17 Club Leon 3 Deportivo Toluca FC 1 B17:00 | 27/04/22 | R 14 Tigres UANL 0 Deportivo Toluca FC 0 G17:00 | 24/04/22 | R 16 Deportivo Toluca FC 2 Atlas 1 G17:00 | 19/04/22 | R 15 Deportivo Toluca FC 2 FC Juarez 0 |
| 7 | |  Tigres UANL | 17 | 8 | 4 | 5 | 26 | 16 | 10 | 28 | |
| 8 | |  Club Santos Laguna | 17 | 8 | 4 | 5 | 23 | 25 | -2 | 28 | B17:00 | 01/05/22 | R 17 Atletico San Luis 2 Club Santos Laguna 2 M19:00 | 24/04/22 | R 16 Club Santos Laguna 0 Club Leon 3 G18:00 | 19/04/22 | R 15 Mazatlan FC 1 Club Santos Laguna 2 B19:00 | 16/04/22 | R 14 Club Santos Laguna 2 Queretaro FC 2 |
| 9 | |  Pumas Unam | 17 | 7 | 4 | 6 | 28 | 20 | 8 | 25 | G17:00 | 01/05/22 | R 17 Pumas Unam 2 Pachuca 1 M17:00 | 23/04/22 | R 16 Chivas Guadalajara 3 Pumas Unam 1 M17:00 | 20/04/22 | R 15 Atletico San Luis 2 Pumas Unam 1 B17:00 | 08/04/22 | R 13 Puebla 2 Pumas Unam 2 M18:00 | 02/04/22 | R 12 FC Juarez 3 Pumas Unam 2 G18:00 | 26/03/22 | R 9 Pumas Unam 3 Mazatlan FC 0 |
| 10 | |  Atletico San Luis | 17 | 7 | 4 | 6 | 33 | 27 | 6 | 25 | B17:00 | 01/05/22 | R 17 Atletico San Luis 2 Club Santos Laguna 2 B17:00 | 24/04/22 | R 16 Cruz Azul 2 Atletico San Luis 2 G17:00 | 20/04/22 | R 15 Atletico San Luis 2 Pumas Unam 1 M17:00 | 15/04/22 | R 14 Necaxa 3 Atletico San Luis 0 B17:00 | 09/04/22 | R 13 Atletico San Luis 1 Club Leon 1 M01:45 | 07/04/22 | R 9 Club Tijuana de Caliente 2 Atletico San Luis 1 |
| 11 | |  Necaxa | 17 | 7 | 2 | 8 | 25 | 25 | 0 | 23 | M17:00 | 29/04/22 | R 17 Necaxa 0 Chivas Guadalajara 3 G17:00 | 22/04/22 | R 16 Puebla 1 Necaxa 3 M17:00 | 19/04/22 | R 15 Necaxa 0 Tigres UANL 2 G17:00 | 15/04/22 | R 14 Necaxa 3 Atletico San Luis 0 B17:00 | 07/04/22 | R 13 Atlas 1 Necaxa 1 M18:00 | 02/04/22 | R 12 Necaxa 1 Club America 2 |
| 12 | |  Cruz Azul | 17 | 5 | 6 | 6 | 18 | 20 | -2 | 21 | M17:00 | 30/04/22 | R 17 Club America 2 Cruz Azul 0 B17:00 | 24/04/22 | R 16 Cruz Azul 2 Atletico San Luis 2 G17:00 | 21/04/22 | R 15 Queretaro FC 1 Cruz Azul 3 G17:00 | 16/04/22 | R 14 Cruz Azul 2 Chivas Guadalajara 1 B18:00 | 08/04/22 | R 13 Mazatlan FC 0 Cruz Azul 0 G18:00 | 02/04/22 | R 12 Cruz Azul 1 Atlas 0 |
| 13 | |  Mazatlan FC | 17 | 6 | 2 | 9 | 20 | 28 | -8 | 20 | G18:00 | 29/04/22 | R 17 Mazatlan FC 4 Puebla 1 M18:00 | 22/04/22 | R 16 FC Juarez 3 Mazatlan FC 0 M18:00 | 19/04/22 | R 15 Mazatlan FC 1 Club Santos Laguna 2 M17:00 | 14/04/22 | R 14 Atlas 3 Mazatlan FC 1 B18:00 | 08/04/22 | R 13 Mazatlan FC 0 Cruz Azul 0 G18:00 | 01/04/22 | R 12 Atletico San Luis 1 Mazatlan FC 2 |
| 14 | |  CF Monterrey | 17 | 5 | 4 | 8 | 18 | 30 | -12 | 19 | G17:00 | 30/04/22 | R 17 CF Monterrey 3 Club Tijuana de Caliente 0 M17:30 | 23/04/22 | R 16 Pachuca 4 CF Monterrey 0 B17:00 | 20/04/22 | R 15 CF Monterrey 0 Atlas 0 M18:00 | 02/04/22 | R 12 Chivas Guadalajara 2 CF Monterrey 1 M18:00 | 26/03/22 | R 13 CF Monterrey 1 Club Santos Laguna 2 G18:00 | 19/03/22 | R 11 Tigres UANL 0 CF Monterrey 1 |
| 15 | |  Atlas | 17 | 3 | 6 | 8 | 13 | 21 | -8 | 15 | B17:00 | 30/04/22 | R 17 Atlas 0 Tigres UANL 0 M17:00 | 24/04/22 | R 16 Deportivo Toluca FC 2 Atlas 1 B17:00 | 20/04/22 | R 15 CF Monterrey 0 Atlas 0 G17:00 | 14/04/22 | R 14 Atlas 3 Mazatlan FC 1 B17:00 | 07/04/22 | R 13 Atlas 1 Necaxa 1 M18:00 | 02/04/22 | R 12 Cruz Azul 1 Atlas 0 |
| 16 | |  FC Juarez | 17 | 3 | 5 | 9 | 15 | 34 | -19 | 14 | B17:00 | 30/04/22 | R 17 Queretaro FC 0 FC Juarez 0 G18:00 | 22/04/22 | R 16 FC Juarez 3 Mazatlan FC 0 M17:00 | 19/04/22 | R 15 Deportivo Toluca FC 2 FC Juarez 0 M18:00 | 15/04/22 | R 14 FC Juarez 0 Pachuca 2 M17:00 | 09/04/22 | R 13 Club America 6 FC Juarez 0 G18:00 | 02/04/22 | R 12 FC Juarez 3 Pumas Unam 2 |
| 17 | |  Puebla | 17 | 2 | 3 | 12 | 18 | 41 | -23 | 9 | M18:00 | 29/04/22 | R 17 Mazatlan FC 4 Puebla 1 M17:00 | 22/04/22 | R 16 Puebla 1 Necaxa 3 B17:30 | 19/04/22 | R 15 Pachuca 2 Puebla 2 M17:00 | 16/04/22 | R 14 Club Leon 4 Puebla 1 B17:00 | 08/04/22 | R 13 Puebla 2 Pumas Unam 2 M17:00 | 03/04/22 | R 12 Deportivo Toluca FC 2 Puebla 0 |
| 18 | |  Queretaro FC | 17 | 1 | 5 | 11 | 9 | 20 | -11 | 8 | B17:00 | 30/04/22 | R 17 Queretaro FC 0 FC Juarez 0 M01:45 | 25/04/22 | R 16 Club Tijuana de Caliente 1 Queretaro FC 0 M17:00 | 21/04/22 | R 15 Queretaro FC 1 Cruz Azul 3 B19:00 | 16/04/22 | R 14 Club Santos Laguna 2 Queretaro FC 2 M17:00 | 10/04/22 | R 13 Queretaro FC 0 Tigres UANL 1 M17:00 | 03/04/22 | R 12 Club Leon 2 Queretaro FC 1 |
