| 1 | |  Club Santos Laguna | 17 | 10 | 4 | 3 | 38 | 21 | 17 | 34 | |
| 2 | |  Cruz Azul | 17 | 7 | 8 | 2 | 15 | 9 | 6 | 29 | |
| 3 | |  Deportivo Toluca FC | 17 | 9 | 2 | 6 | 24 | 19 | 5 | 29 | G18:00 | 05/11/21 | R 17  Puebla 0 Deportivo Toluca FC 3 G18:00 | 31/10/21 | R 16 Deportivo Toluca FC 1 Club Leon 0 M19:00 | 24/10/21 | R 15 Club Santos Laguna 3 Deportivo Toluca FC 0 M17:00 | 20/10/21 | R 14 Deportivo Toluca FC 0 Necaxa 1 |
| 4 | |  Club America | 17 | 7 | 6 | 4 | 25 | 19 | 6 | 27 | G18:00 | 06/11/21 | R 17 Club America 2 CF Monterrey 0 B18:00 | 31/10/21 | R 16 Cruz Azul 1 Club America 1 G17:00 | 23/10/21 | R 15 Club America 2 Tigres UANL 1 M17:00 | 16/10/21 | R 13 Atletico San Luis 1 Club America 0 |
| 5 | |  Tigres UANL | 17 | 8 | 2 | 7 | 24 | 19 | 5 | 26 | G18:00 | 06/11/21 | R 17 Tigres UANL 1 FC Juarez 0 G17:00 | 30/10/21 | R 16 Tigres UANL 3 Chivas Guadalajara 0 |
| 6 | |  Atlas | 17 | 7 | 5 | 5 | 23 | 21 | 2 | 26 | B18:00 | 04/11/21 | R 17 Atlas 1 Queretaro FC 1 B17:00 | 28/10/21 | R 16 Atlas 1 Club Tijuana de Caliente 1 |
| 7 | |  Mazatlan FC | 17 | 7 | 4 | 6 | 31 | 30 | 1 | 25 | G18:30 | 05/11/21 | R 17 Mazatlan FC 1 Chivas Guadalajara 0 B17:00 | 29/10/21 | R 16 Necaxa 1 Mazatlan FC 1 G17:30 | 22/10/21 | R 15 Mazatlan FC 4 Queretaro FC 0 M17:00 | 19/10/21 | R 14 Puebla 2 Mazatlan FC 1 |
| 8 | |  Club Leon | 17 | 7 | 3 | 7 | 19 | 19 | 0 | 24 | G18:00 | 06/11/21 | R 17 Club Leon 3 Necaxa 1 M18:00 | 03/11/21 | R 11 Cruz Azul 2 Club Leon 0 M18:00 | 31/10/21 | R 16 Deportivo Toluca FC 1 Club Leon 0 M17:00 | 23/10/21 | R 15 Puebla 2 Club Leon 1 |
| 9 | |  Atletico San Luis | 17 | 7 | 2 | 8 | 27 | 27 | 0 | 23 | M20:00 | 07/11/21 | R 17 Club Santos Laguna 2 Atletico San Luis 1 G21:00 | 03/11/21 | R 5 Pachuca 1 Atletico San Luis 3 G18:00 | 31/10/21 | R 16 Atletico San Luis 3 CF Monterrey 1 M17:00 | 24/10/21 | R 15 Atletico San Luis 0 Atlas 2 G17:00 | 16/10/21 | R 13 Atletico San Luis 1 Club America 0 M17:00 | 02/10/21 | R 12 Club Leon 2 Atletico San Luis 0 |
| 10 | |  Chivas Guadalajara | 17 | 7 | 2 | 8 | 22 | 26 | -4 | 23 | M18:30 | 05/11/21 | R 17 Mazatlan FC 1 Chivas Guadalajara 0 M17:00 | 30/10/21 | R 16 Tigres UANL 3 Chivas Guadalajara 0 M17:00 | 23/10/21 | R 15 Chivas Guadalajara 0 Cruz Azul 1 G01:45 | 21/10/21 | R 14 Club Tijuana de Caliente 1 Chivas Guadalajara 2 G17:00 | 17/10/21 | R 13 Chivas Guadalajara 4 Deportivo Toluca FC 1 M17:00 | 02/10/21 | R 12 Chivas Guadalajara 0 Atlas 2 |
| 11 | |  Pachuca | 17 | 5 | 7 | 5 | 24 | 19 | 5 | 22 | M19:00 | 10/11/21 | R 17 Club Tijuana de Caliente 2 Pachuca 1 M21:00 | 03/11/21 | R 5 Pachuca 1 Atletico San Luis 3 G20:00 | 30/10/21 | R 16 Pachuca 1 Pumas Unam 0 G20:00 | 24/10/21 | R 15 Pachuca 6 FC Juarez 0 M17:00 | 20/10/21 | R 14 Tigres UANL 2 Pachuca 1 B20:00 | 16/10/21 | R 13 Pachuca 2 Club Santos Laguna 2 |
| 12 | |  Puebla | 17 | 5 | 7 | 5 | 26 | 31 | -5 | 22 | M18:00 | 05/11/21 | R 17 Puebla 0 Deportivo Toluca FC 3 B18:00 | 29/10/21 | R 16 FC Juarez 1 Puebla 1 G17:00 | 23/10/21 | R 15 Puebla 2 Club Leon 1 G17:00 | 19/10/21 | R 14 Puebla 2 Mazatlan FC 1 B17:00 | 15/10/21 | R 13 Necaxa 1 Puebla 1 B17:00 | 01/10/21 | R 12 Puebla 1 Pachuca 1 |
| 13 | |  Pumas Unam | 17 | 6 | 3 | 8 | 27 | 26 | 1 | 21 | M18:00 | 07/11/21 | R 17 Pumas Unam 1 Cruz Azul 2 G18:00 | 04/11/21 | R 11 Pumas Unam 2 Club Santos Laguna 1 M20:00 | 30/10/21 | R 16 Pachuca 1 Pumas Unam 0 G17:00 | 24/10/21 | R 15 Pumas Unam 4 Club Tijuana de Caliente 0 G17:00 | 20/10/21 | R 14 Club Leon 0 Pumas Unam 2 G17:00 | 17/10/21 | R 13 Pumas Unam 3 FC Juarez 0 |
| 14 | |  Necaxa | 17 | 5 | 6 | 6 | 25 | 28 | -3 | 21 | M18:00 | 06/11/21 | R 17 Club Leon 3 Necaxa 1 B17:00 | 29/10/21 | R 16 Necaxa 1 Mazatlan FC 1 M17:00 | 23/10/21 | R 15 CF Monterrey 5 Necaxa 1 G17:00 | 20/10/21 | R 14 Deportivo Toluca FC 0 Necaxa 1 B17:00 | 15/10/21 | R 13 Necaxa 1 Puebla 1 M17:00 | 03/10/21 | R 12 Tigres UANL 3 Necaxa 2 |
| 15 | |  Club Tijuana de Caliente | 17 | 5 | 6 | 6 | 25 | 29 | -4 | 21 | G19:00 | 10/11/21 | R 17 Club Tijuana de Caliente 2 Pachuca 1 B17:00 | 28/10/21 | R 16 Atlas 1 Club Tijuana de Caliente 1 M17:00 | 24/10/21 | R 15 Pumas Unam 4 Club Tijuana de Caliente 0 M01:45 | 21/10/21 | R 14 Club Tijuana de Caliente 1 Chivas Guadalajara 2 B17:00 | 14/10/21 | R 13 Queretaro FC 3 Club Tijuana de Caliente 3 M01:45 | 04/10/21 | R 12 Club Tijuana de Caliente 0 Cruz Azul 1 |
| 16 | |  CF Monterrey | 17 | 5 | 4 | 8 | 25 | 25 | 0 | 19 | M18:00 | 06/11/21 | R 17 Club America 2 CF Monterrey 0 M18:00 | 31/10/21 | R 16 Atletico San Luis 3 CF Monterrey 1 G17:00 | 23/10/21 | R 15 CF Monterrey 5 Necaxa 1 B17:00 | 19/10/21 | R 14 Queretaro FC 1 CF Monterrey 1 B17:00 | 16/10/21 | R 13 CF Monterrey 1 Club Leon 1 M18:00 | 01/10/21 | R 12 FC Juarez 1 CF Monterrey 0 |
| 17 | |  Queretaro FC | 17 | 4 | 6 | 7 | 19 | 29 | -10 | 18 | B18:00 | 04/11/21 | R 17 Atlas 1 Queretaro FC 1 M17:00 | 30/10/21 | R 16 Queretaro FC 0 Club Santos Laguna 5 M17:30 | 22/10/21 | R 15 Mazatlan FC 4 Queretaro FC 0 B17:00 | 19/10/21 | R 14 Queretaro FC 1 CF Monterrey 1 B17:00 | 14/10/21 | R 13 Queretaro FC 3 Club Tijuana de Caliente 3 M17:00 | 03/10/21 | R 12 Deportivo Toluca FC 2 Queretaro FC 0 |
| 18 | |  FC Juarez | 17 | 1 | 5 | 11 | 11 | 33 | -22 | 8 | M18:00 | 06/11/21 | R 17 Tigres UANL 1 FC Juarez 0 B18:00 | 29/10/21 | R 16 FC Juarez 1 Puebla 1 M20:00 | 24/10/21 | R 15 Pachuca 6 FC Juarez 0 M17:00 | 17/10/21 | R 13 Pumas Unam 3 FC Juarez 0 G18:00 | 01/10/21 | R 12 FC Juarez 1 CF Monterrey 0 B17:30 | 28/09/21 | R 11 Mazatlan FC 2 FC Juarez 2 |
