| 1 | |  FC Shakhtar Donetsk | 26 | 19 | 5 | 2 | 55 | 10 | 45 | 62 | G12:00 | 09/05/21 | R 26  FC Shakhtar Donetsk 3 FC Ingulets U19 0 G12:00 | 06/05/21 | R 25 FC Minaj U19 1 FC Shakhtar Donetsk 7 G12:00 | 01/05/21 | R 24 FC Shakhtar Donetsk 1 SC Dnipro-1 0 G11:00 | 25/04/21 | R 23 FC Oleksandria 0 FC Shakhtar Donetsk 5 G12:00 | 17/04/21 | R 22 FC Shakhtar Donetsk 1 FC Dynamo Kiev 0 G12:00 | 10/04/21 | R 21 FC Mariupol 0 FC Shakhtar Donetsk 1 |
| 2 | |  FC Dynamo Kiev | 23 | 17 | 2 | 4 | 60 | 18 | 42 | 53 | G12:00 | 09/05/21 | R 26 Kolos Kovalivka 0 FC Dynamo Kiev 4 G12:00 | 06/05/21 | R 25 FC Dynamo Kiev 4 FC Mariupol 1 G12:00 | 01/05/21 | R 24 FC Vorskla Poltava 1 FC Dynamo Kiev 3 B17:00 | 23/04/21 | R 23 FC Dynamo Kiev 1 FC Ingulets U19 1 M12:00 | 17/04/21 | R 22 FC Shakhtar Donetsk 1 FC Dynamo Kiev 0 G13:00 | 10/04/21 | R 21 FC Dynamo Kiev 1 SC Dnipro-1 0 |
| 3 | |  FC Zorya Lugansk | 25 | 15 | 5 | 5 | 45 | 27 | 18 | 50 | G12:00 | 08/05/21 | R 26 FC Zorya Lugansk 2 FC Oleksandria 0 G12:00 | 05/05/21 | R 25 SC Dnipro-1 2 FC Zorya Lugansk 3 G11:00 | 01/05/21 | R 24 FC Zorya Lugansk 3 FC Minaj U19 0 B11:00 | 24/04/21 | R 23 FC Zorya Lugansk 1 FC Olimpik Donetsk 1 M13:00 | 17/04/21 | R 22 FC Vorskla Poltava 4 FC Zorya Lugansk 0 G14:00 | 11/04/21 | R 21 FC Zorya Lugansk 3 FC Ingulets U19 1 |
| 4 | |  FC Rukh LVIV U19 | 25 | 13 | 6 | 6 | 48 | 24 | 24 | 45 | B12:00 | 09/05/21 | R 26 SC Dnipro-1 2 FC Rukh LVIV U19 2 G12:00 | 05/05/21 | R 25 FC Rukh LVIV U19 7 FC Olimpik Donetsk 2 M12:00 | 01/05/21 | R 24 FC Rukh LVIV U19 0 FC Oleksandria 1 G14:00 | 24/04/21 | R 23 FC Mariupol 1 FC Rukh LVIV U19 4 G14:00 | 18/04/21 | R 22 FC Ingulets U19 0 FC Rukh LVIV U19 4 G12:00 | 11/04/21 | R 21 FC Rukh LVIV U19 2 FC Minaj U19 0 |
| 5 | |  FC Vorskla Poltava | 25 | 13 | 4 | 8 | 49 | 27 | 22 | 43 | G11:00 | 09/05/21 | R 26 FC Minaj U19 3 FC Vorskla Poltava 5 G12:00 | 05/05/21 | R 25 FC Vorskla Poltava 5 FC Desna Chernihiv 1 M12:00 | 01/05/21 | R 24 FC Vorskla Poltava 1 FC Dynamo Kiev 3 M12:00 | 24/04/21 | R 23 Kolos Kovalivka 2 FC Vorskla Poltava 1 G13:00 | 17/04/21 | R 22 FC Vorskla Poltava 4 FC Zorya Lugansk 0 G11:00 | 11/04/21 | R 21 FC Vorskla Poltava 2 FC Lviv 0 |
| 5 | |  FC Rukh LVIV | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 6 | |  Kolos Kovalivka | 25 | 11 | 6 | 8 | 30 | 32 | -2 | 39 | M12:00 | 09/05/21 | R 26 Kolos Kovalivka 0 FC Dynamo Kiev 4 M11:00 | 05/05/21 | R 25 FC Oleksandria 3 Kolos Kovalivka 0 G11:00 | 01/05/21 | R 24 FC Desna Chernihiv 0 Kolos Kovalivka 4 G12:00 | 24/04/21 | R 23 Kolos Kovalivka 2 FC Vorskla Poltava 1 G11:00 | 18/04/21 | R 22 Kolos Kovalivka 2 SC Dnipro-1 1 B19:00 | 11/04/21 | R 21 FC Olimpik Donetsk 1 Kolos Kovalivka 1 |
| 7 | |  FC Oleksandria | 25 | 11 | 5 | 9 | 29 | 34 | -5 | 38 | M12:00 | 08/05/21 | R 26 FC Zorya Lugansk 2 FC Oleksandria 0 G11:00 | 05/05/21 | R 25 FC Oleksandria 3 Kolos Kovalivka 0 G12:00 | 01/05/21 | R 24 FC Rukh LVIV U19 0 FC Oleksandria 1 M11:00 | 25/04/21 | R 23 FC Oleksandria 0 FC Shakhtar Donetsk 5 G12:00 | 16/04/21 | R 22 FC Lviv 2 FC Oleksandria 3 B11:00 | 10/04/21 | R 21 FC Desna Chernihiv 1 FC Oleksandria 1 |
| 8 | |  FC Lviv | 24 | 8 | 8 | 8 | 33 | 31 | 2 | 32 | G12:00 | 09/05/21 | R 26 FC Lviv 1 FC Olimpik Donetsk 0 G11:00 | 05/05/21 | R 25 FC Ingulets U19 1 FC Lviv 3 B12:00 | 30/04/21 | R 24 FC Mariupol 1 FC Lviv 1 B11:00 | 24/04/21 | R 23 FC Lviv 2 FC Desna Chernihiv 2 M12:00 | 16/04/21 | R 22 FC Lviv 2 FC Oleksandria 3 M11:00 | 11/04/21 | R 21 FC Vorskla Poltava 2 FC Lviv 0 |
| 9 | |  FC Mariupol | 26 | 8 | 7 | 11 | 29 | 39 | -10 | 31 | G13:00 | 09/05/21 | R 26 FC Mariupol 2 FC Desna Chernihiv 1 M12:00 | 06/05/21 | R 25 FC Dynamo Kiev 4 FC Mariupol 1 B12:00 | 30/04/21 | R 24 FC Mariupol 1 FC Lviv 1 M14:00 | 24/04/21 | R 23 FC Mariupol 1 FC Rukh LVIV U19 4 B12:00 | 18/04/21 | R 22 FC Mariupol 2 FC Olimpik Donetsk 2 M12:00 | 10/04/21 | R 21 FC Mariupol 0 FC Shakhtar Donetsk 1 |
| 10 | |  FC Ingulets U19 | 26 | 7 | 5 | 14 | 27 | 51 | -24 | 26 | M12:00 | 09/05/21 | R 26 FC Shakhtar Donetsk 3 FC Ingulets U19 0 M11:00 | 05/05/21 | R 25 FC Ingulets U19 1 FC Lviv 3 M12:00 | 02/05/21 | R 24 FC Olimpik Donetsk 3 FC Ingulets U19 1 B17:00 | 23/04/21 | R 23 FC Dynamo Kiev 1 FC Ingulets U19 1 M14:00 | 18/04/21 | R 22 FC Ingulets U19 0 FC Rukh LVIV U19 4 M14:00 | 11/04/21 | R 21 FC Zorya Lugansk 3 FC Ingulets U19 1 |
| 11 | |  SC Dnipro-1 | 25 | 7 | 4 | 14 | 31 | 38 | -7 | 25 | B12:00 | 09/05/21 | R 26 SC Dnipro-1 2 FC Rukh LVIV U19 2 M12:00 | 05/05/21 | R 25 SC Dnipro-1 2 FC Zorya Lugansk 3 M12:00 | 01/05/21 | R 24 FC Shakhtar Donetsk 1 SC Dnipro-1 0 G11:00 | 23/04/21 | R 23 SC Dnipro-1 2 FC Minaj U19 0 M11:00 | 18/04/21 | R 22 Kolos Kovalivka 2 SC Dnipro-1 1 M13:00 | 10/04/21 | R 21 FC Dynamo Kiev 1 SC Dnipro-1 0 |
| 12 | |  FC Olimpik Donetsk | 24 | 4 | 7 | 13 | 27 | 52 | -25 | 19 | M12:00 | 09/05/21 | R 26 FC Lviv 1 FC Olimpik Donetsk 0 M12:00 | 05/05/21 | R 25 FC Rukh LVIV U19 7 FC Olimpik Donetsk 2 G12:00 | 02/05/21 | R 24 FC Olimpik Donetsk 3 FC Ingulets U19 1 B11:00 | 24/04/21 | R 23 FC Zorya Lugansk 1 FC Olimpik Donetsk 1 B12:00 | 18/04/21 | R 22 FC Mariupol 2 FC Olimpik Donetsk 2 B19:00 | 11/04/21 | R 21 FC Olimpik Donetsk 1 Kolos Kovalivka 1 |
| 13 | |  FC Desna Chernihiv | 24 | 1 | 8 | 15 | 15 | 54 | -39 | 11 | M13:00 | 09/05/21 | R 26 FC Mariupol 2 FC Desna Chernihiv 1 M12:00 | 05/05/21 | R 25 FC Vorskla Poltava 5 FC Desna Chernihiv 1 M11:00 | 01/05/21 | R 24 FC Desna Chernihiv 0 Kolos Kovalivka 4 B11:00 | 24/04/21 | R 23 FC Lviv 2 FC Desna Chernihiv 2 M15:30 | 16/04/21 | R 22 FC Minaj U19 1 FC Desna Chernihiv 0 B11:00 | 10/04/21 | R 21 FC Desna Chernihiv 1 FC Oleksandria 1 |
| 14 | |  FC Minaj U19 | 25 | 2 | 4 | 19 | 13 | 54 | -41 | 10 | M11:00 | 09/05/21 | R 26 FC Minaj U19 3 FC Vorskla Poltava 5 M12:00 | 06/05/21 | R 25 FC Minaj U19 1 FC Shakhtar Donetsk 7 M11:00 | 01/05/21 | R 24 FC Zorya Lugansk 3 FC Minaj U19 0 M11:00 | 23/04/21 | R 23 SC Dnipro-1 2 FC Minaj U19 0 G15:30 | 16/04/21 | R 22 FC Minaj U19 1 FC Desna Chernihiv 0 M12:00 | 11/04/21 | R 21 FC Rukh LVIV U19 2 FC Minaj U19 0 |
