| 1 | |  FC Barcelona | 29 | 29 | 0 | 0 | 157 | 10 | 147 | 87 | G17:00 | 08/05/22 | R 29  Rayo Vallecano 1 FC Barcelona 6 G18:00 | 05/05/22 | R 28 FC Barcelona 5 Sevilla FC 1 G13:00 | 16/04/22 | R 27 Valencia CF 0 FC Barcelona 2 G13:00 | 02/04/22 | R 26 FC Barcelona 6 Villarreal CF 1 G14:00 | 26/03/22 | R 25 Madrid Ccf 1 FC Barcelona 2 G14:00 | 13/03/22 | R 24 FC Barcelona 5 Real Madrid 0 |
| 2 | |  Real Sociedad San Sebastian | 29 | 20 | 3 | 6 | 61 | 37 | 24 | 63 | B13:00 | 08/05/22 | R 29 UDG Tenerife 1 Real Sociedad San Sebastian 1 G13:00 | 01/05/22 | R 28 Real Sociedad San Sebastian 4 Rayo Vallecano 0 G13:00 | 16/04/22 | R 27 Sevilla FC 1 Real Sociedad San Sebastian 2 M13:30 | 02/04/22 | R 26 Real Sociedad San Sebastian 0 Madrid Ccf 1 G13:00 | 27/03/22 | R 25 Sporting Club de Huelva 1 Real Sociedad San Sebastian 2 G15:00 | 12/03/22 | R 24 Real Betis Seville 0 Real Sociedad San Sebastian 3 |
| 3 | |  Atletico Madrid | 29 | 17 | 8 | 4 | 70 | 26 | 44 | 59 | G13:00 | 08/05/22 | R 29 Atletico Madrid 3 SD Eibar 1 G12:00 | 01/05/22 | R 28 Levante UD 0 Atletico Madrid 5 G13:00 | 17/04/22 | R 27 Atletico Madrid 3 Athletic Bilbao 0 B18:00 | 02/04/22 | R 26 Real Betis Seville 1 Atletico Madrid 1 G15:00 | 26/03/22 | R 25 Atletico Madrid 3 Valencia CF 0 B13:00 | 13/03/22 | R 24 Rayo Vallecano 0 Atletico Madrid 0 |
| 4 | |  Real Madrid | 29 | 18 | 3 | 8 | 40 | 31 | 9 | 57 | B13:00 | 08/05/22 | R 29 Valencia CF 0 Real Madrid 0 G12:00 | 01/05/22 | R 28 Real Madrid 1 Madrid Ccf 0 G18:00 | 20/04/22 | R 18 Rayo Vallecano 0 Real Madrid 1 G12:00 | 17/04/22 | R 27 Deportivo Alaves 0 Real Madrid 1 M13:00 | 03/04/22 | R 26 Sporting Club de Huelva 3 Real Madrid 1 G14:00 | 26/03/22 | R 25 Real Madrid 1 Levante UD 0 |
| 5 | |  UDG Tenerife | 29 | 16 | 6 | 7 | 41 | 40 | 1 | 54 | M21:30 | 14/05/22 | R 30 Levante UD 4 UDG Tenerife 1 B13:00 | 08/05/22 | R 29 UDG Tenerife 1 Real Sociedad San Sebastian 1 M13:00 | 30/04/22 | R 28 Athletic Bilbao 2 UDG Tenerife 1 G14:00 | 16/04/22 | R 27 UDG Tenerife 3 SD Eibar 2 G13:00 | 03/04/22 | R 26 Rayo Vallecano 1 UDG Tenerife 2 B14:00 | 27/03/22 | R 25 UDG Tenerife 0 Real Betis Seville 0 |
| 6 | |  Levante UD | 29 | 14 | 5 | 10 | 48 | 38 | 10 | 47 | G21:30 | 14/05/22 | R 30 Levante UD 4 UDG Tenerife 1 G17:00 | 08/05/22 | R 29 Madrid Ccf 1 Levante UD 3 M12:00 | 01/05/22 | R 28 Levante UD 0 Atletico Madrid 5 G12:00 | 17/04/22 | R 27 Rayo Vallecano 3 Levante UD 4 G12:00 | 03/04/22 | R 26 Levante UD 3 Sevilla FC 0 G17:00 | 30/03/22 | R 24 Levante UD 3 Deportivo Alaves 0 |
| 7 | |  Athletic Bilbao | 29 | 14 | 5 | 10 | 44 | 43 | 1 | 47 | G13:00 | 07/05/22 | R 29 Deportivo Alaves 1 Athletic Bilbao 3 G13:00 | 30/04/22 | R 28 Athletic Bilbao 2 UDG Tenerife 1 M13:00 | 17/04/22 | R 27 Atletico Madrid 3 Athletic Bilbao 0 B13:00 | 02/04/22 | R 26 Athletic Bilbao 2 Valencia CF 2 B19:00 | 26/03/22 | R 25 Villarreal CF 1 Athletic Bilbao 1 G14:15 | 12/03/22 | R 24 Athletic Bilbao 2 Madrid Ccf 1 |
| 8 | |  Sevilla FC | 29 | 9 | 8 | 12 | 33 | 51 | -18 | 35 | G13:00 | 08/05/22 | R 29 Sevilla FC 3 Sporting Club de Huelva 1 M18:00 | 05/05/22 | R 28 FC Barcelona 5 Sevilla FC 1 M13:00 | 16/04/22 | R 27 Sevilla FC 1 Real Sociedad San Sebastian 2 M12:00 | 03/04/22 | R 26 Levante UD 3 Sevilla FC 0 G14:00 | 26/03/22 | R 25 Sevilla FC 4 SD Eibar 1 M15:00 | 13/03/22 | R 24 UDG Tenerife 1 Sevilla FC 0 |
| 9 | |  Real Betis Seville | 30 | 7 | 10 | 13 | 31 | 52 | -21 | 31 | M12:30 | 14/05/22 | R 30 Real Betis Seville 1 Rayo Vallecano 3 M13:00 | 08/05/22 | R 29 Villarreal CF 2 Real Betis Seville 0 B12:30 | 30/04/22 | R 28 Real Betis Seville 0 Valencia CF 0 B13:00 | 17/04/22 | R 27 Madrid Ccf 2 Real Betis Seville 2 B18:00 | 02/04/22 | R 26 Real Betis Seville 1 Atletico Madrid 1 B14:00 | 27/03/22 | R 25 UDG Tenerife 0 Real Betis Seville 0 |
| 10 | |  Deportivo Alaves | 29 | 8 | 6 | 15 | 29 | 57 | -28 | 30 | M13:00 | 07/05/22 | R 29 Deportivo Alaves 1 Athletic Bilbao 3 M13:00 | 01/05/22 | R 28 Sporting Club de Huelva 2 Deportivo Alaves 1 M12:00 | 17/04/22 | R 27 Deportivo Alaves 0 Real Madrid 1 M12:30 | 03/04/22 | R 26 SD Eibar 2 Deportivo Alaves 0 M17:00 | 30/03/22 | R 24 Levante UD 3 Deportivo Alaves 0 G18:30 | 26/03/22 | R 25 Deportivo Alaves 3 Rayo Vallecano 1 |
| 11 | |  Villarreal CF | 29 | 8 | 5 | 16 | 29 | 62 | -33 | 29 | G13:00 | 08/05/22 | R 29 Villarreal CF 2 Real Betis Seville 0 B12:30 | 01/05/22 | R 28 SD Eibar 1 Villarreal CF 1 B13:00 | 17/04/22 | R 27 Villarreal CF 1 Sporting Club de Huelva 1 M13:00 | 02/04/22 | R 26 FC Barcelona 6 Villarreal CF 1 M19:00 | 30/03/22 | R 24 Valencia CF 2 Villarreal CF 1 B19:00 | 26/03/22 | R 25 Villarreal CF 1 Athletic Bilbao 1 |
| 12 | |  Sporting Club de Huelva | 29 | 5 | 13 | 11 | 26 | 44 | -18 | 28 | M13:00 | 08/05/22 | R 29 Sevilla FC 3 Sporting Club de Huelva 1 G13:00 | 01/05/22 | R 28 Sporting Club de Huelva 2 Deportivo Alaves 1 B13:00 | 17/04/22 | R 27 Villarreal CF 1 Sporting Club de Huelva 1 G13:00 | 03/04/22 | R 26 Sporting Club de Huelva 3 Real Madrid 1 M13:00 | 27/03/22 | R 25 Sporting Club de Huelva 1 Real Sociedad San Sebastian 2 G14:00 | 12/03/22 | R 24 SD Eibar 1 Sporting Club de Huelva 2 |
| 13 | |  Madrid Ccf | 29 | 8 | 3 | 18 | 42 | 62 | -20 | 27 | M17:00 | 08/05/22 | R 29 Madrid Ccf 1 Levante UD 3 M12:00 | 01/05/22 | R 28 Real Madrid 1 Madrid Ccf 0 B13:00 | 17/04/22 | R 27 Madrid Ccf 2 Real Betis Seville 2 G13:30 | 02/04/22 | R 26 Real Sociedad San Sebastian 0 Madrid Ccf 1 M14:00 | 26/03/22 | R 25 Madrid Ccf 1 FC Barcelona 2 M14:15 | 12/03/22 | R 24 Athletic Bilbao 2 Madrid Ccf 1 |
| 14 | |  Valencia CF | 29 | 7 | 6 | 16 | 26 | 51 | -25 | 27 | B13:00 | 08/05/22 | R 29 Valencia CF 0 Real Madrid 0 B12:30 | 30/04/22 | R 28 Real Betis Seville 0 Valencia CF 0 M13:00 | 16/04/22 | R 27 Valencia CF 0 FC Barcelona 2 B13:00 | 02/04/22 | R 26 Athletic Bilbao 2 Valencia CF 2 G19:00 | 30/03/22 | R 24 Valencia CF 2 Villarreal CF 1 M15:00 | 26/03/22 | R 25 Atletico Madrid 3 Valencia CF 0 |
| 15 | |  SD Eibar | 29 | 6 | 2 | 21 | 30 | 62 | -32 | 20 | M13:00 | 08/05/22 | R 29 Atletico Madrid 3 SD Eibar 1 B12:30 | 01/05/22 | R 28 SD Eibar 1 Villarreal CF 1 M14:00 | 16/04/22 | R 27 UDG Tenerife 3 SD Eibar 2 G12:30 | 03/04/22 | R 26 SD Eibar 2 Deportivo Alaves 0 M14:00 | 26/03/22 | R 25 Sevilla FC 4 SD Eibar 1 M14:00 | 12/03/22 | R 24 SD Eibar 1 Sporting Club de Huelva 2 |
| 16 | |  Rayo Vallecano | 30 | 3 | 5 | 22 | 27 | 68 | -41 | 14 | G12:30 | 14/05/22 | R 30 Real Betis Seville 1 Rayo Vallecano 3 M17:00 | 08/05/22 | R 29 Rayo Vallecano 1 FC Barcelona 6 M13:00 | 01/05/22 | R 28 Real Sociedad San Sebastian 4 Rayo Vallecano 0 M18:00 | 20/04/22 | R 18 Rayo Vallecano 0 Real Madrid 1 M12:00 | 17/04/22 | R 27 Rayo Vallecano 3 Levante UD 4 M13:00 | 03/04/22 | R 26 Rayo Vallecano 1 UDG Tenerife 2 |
