| 1 | |  FK Zenit St Petersburg | 20 | 12 | 6 | 2 | 45 | 17 | 28 | 42 | B16:30 | 27/02/21 | R 20  FK Zenit St Petersburg 2 FC Rostov 2 G20:00 | 16/12/20 | R 19 FK Zenit St Petersburg 3 FK Spartak Moskova 1 G19:00 | 12/12/20 | R 18 FK Zenit St Petersburg 3 FK Dinamo Moscow 1 G19:00 | 05/12/20 | R 17 FK Zenit St Petersburg 5 Ural Ekaterinburg 1 B14:00 | 28/11/20 | R 16 PFK Arsenal Tula 0 FK Zenit St Petersburg 0 B16:30 | 21/11/20 | R 15 RFK Akhmat Grozny 2 FK Zenit St Petersburg 2 |
| 2 | |  CSKA Moskova | 20 | 11 | 4 | 5 | 35 | 19 | 16 | 37 | M19:00 | 27/02/21 | R 20 FK Lokomotiv Moskova 2 CSKA Moskova 0 G20:00 | 17/12/20 | R 19 FC Rostov 1 CSKA Moskova 3 B19:00 | 13/12/20 | R 18 CSKA Moskova 2 Ural Ekaterinburg 2 B19:00 | 06/12/20 | R 17 CSKA Moskova 2 FK Khimki 2 M16:30 | 29/11/20 | R 16 FK Rubin Kazan 1 CSKA Moskova 0 B14:00 | 22/11/20 | R 15 CSKA Moskova 1 PFK Sochi 1 |
| 3 | |  PFK Sochi | 20 | 10 | 6 | 4 | 32 | 22 | 10 | 36 | G19:00 | 27/02/21 | R 20 PFK Sochi 4 PFK Arsenal Tula 0 G18:00 | 16/12/20 | R 19 PFK Sochi 2 FK Dinamo Moscow 0 G16:30 | 12/12/20 | R 18 PFK Sochi 1 FK Spartak Moskova 0 G19:00 | 07/12/20 | R 17 PFK Sochi 2 RFK Akhmat Grozny 0 M12:00 | 29/11/20 | R 16 Ural Ekaterinburg 1 PFK Sochi 0 B14:00 | 22/11/20 | R 15 CSKA Moskova 1 PFK Sochi 1 |
| 4 | |  FK Spartak Moskova | 20 | 10 | 5 | 5 | 33 | 23 | 10 | 35 | M14:00 | 28/02/21 | R 20 FK Spartak Moskova 0 FK Rubin Kazan 2 M20:00 | 16/12/20 | R 19 FK Zenit St Petersburg 3 FK Spartak Moskova 1 M16:30 | 12/12/20 | R 18 PFK Sochi 1 FK Spartak Moskova 0 G16:30 | 05/12/20 | R 17 FK Spartak Moskova 5 FK Tambov 1 G19:00 | 29/11/20 | R 16 FK Spartak Moskova 2 SK Rotor 0 B19:00 | 21/11/20 | R 15 FK Spartak Moskova 1 FK Dinamo Moscow 1 |
| 5 | |  FC Rostov | 20 | 10 | 3 | 7 | 26 | 22 | 4 | 33 | B16:30 | 27/02/21 | R 20 FK Zenit St Petersburg 2 FC Rostov 2 M20:00 | 17/12/20 | R 19 FC Rostov 1 CSKA Moskova 3 G19:00 | 13/12/20 | R 18 RFK Akhmat Grozny 0 FC Rostov 1 M14:00 | 06/12/20 | R 17 FC Rostov 0 FK Ufa 1 G19:00 | 28/11/20 | R 16 FC Rostov 4 FK Dinamo Moscow 1 G19:00 | 22/11/20 | R 15 FK Rubin Kazan 0 FC Rostov 2 |
| 6 | |  FK Dinamo Moscow | 20 | 10 | 3 | 7 | 26 | 22 | 4 | 33 | G16:30 | 28/02/21 | R 20 RFK Akhmat Grozny 1 FK Dinamo Moscow 2 M18:00 | 16/12/20 | R 19 PFK Sochi 2 FK Dinamo Moscow 0 M19:00 | 12/12/20 | R 18 FK Zenit St Petersburg 3 FK Dinamo Moscow 1 G16:30 | 06/12/20 | R 17 FK Dinamo Moscow 1 PFK Arsenal Tula 0 M19:00 | 28/11/20 | R 16 FC Rostov 4 FK Dinamo Moscow 1 B19:00 | 21/11/20 | R 15 FK Spartak Moskova 1 FK Dinamo Moscow 1 |
| 7 | |  FK Lokomotiv Moskova | 20 | 9 | 4 | 7 | 23 | 25 | -2 | 31 | G19:00 | 27/02/21 | R 20 FK Lokomotiv Moskova 2 CSKA Moskova 0 M18:00 | 17/12/20 | R 19 FK Khimki 3 FK Lokomotiv Moskova 2 M16:30 | 13/12/20 | R 18 FC Krasnodar 5 FK Lokomotiv Moskova 0 G14:00 | 05/12/20 | R 17 FK Lokomotiv Moskova 3 FK Rubin Kazan 1 B19:00 | 28/11/20 | R 16 RFK Akhmat Grozny 0 FK Lokomotiv Moskova 0 G19:00 | 21/11/20 | R 15 FK Lokomotiv Moskova 1 PFK Arsenal Tula 0 |
| 8 | |  FC Krasnodar | 20 | 9 | 4 | 7 | 37 | 21 | 16 | 31 | B19:00 | 28/02/21 | R 20 FC Krasnodar 2 Ural Ekaterinburg 2 G18:00 | 17/12/20 | R 19 FC Krasnodar 1 FK Ufa 0 G16:30 | 13/12/20 | R 18 FC Krasnodar 5 FK Lokomotiv Moskova 0 G19:00 | 05/12/20 | R 17 FC Krasnodar 5 SK Rotor 0 M16:30 | 28/11/20 | R 16 FK Khimki 1 FC Krasnodar 0 G14:00 | 21/11/20 | R 15 FC Krasnodar 1 FK Tambov 0 |
| 9 | |  FK Rubin Kazan | 20 | 9 | 4 | 7 | 26 | 25 | 1 | 31 | G14:00 | 28/02/21 | R 20 FK Spartak Moskova 0 FK Rubin Kazan 2 B20:00 | 17/12/20 | R 19 RFK Akhmat Grozny 0 FK Rubin Kazan 0 G14:00 | 13/12/20 | R 18 FK Tambov 0 FK Rubin Kazan 1 M14:00 | 05/12/20 | R 17 FK Lokomotiv Moskova 3 FK Rubin Kazan 1 G16:30 | 29/11/20 | R 16 FK Rubin Kazan 1 CSKA Moskova 0 M19:00 | 22/11/20 | R 15 FK Rubin Kazan 0 FC Rostov 2 |
| 10 | |  FK Khimki | 20 | 8 | 4 | 8 | 26 | 31 | -5 | 28 | G14:00 | 27/02/21 | R 20 FK Khimki 2 FK Ufa 1 G18:00 | 17/12/20 | R 19 FK Khimki 3 FK Lokomotiv Moskova 2 G19:00 | 11/12/20 | R 18 FK Khimki 1 PFK Arsenal Tula 0 B19:00 | 06/12/20 | R 17 CSKA Moskova 2 FK Khimki 2 G16:30 | 28/11/20 | R 16 FK Khimki 1 FC Krasnodar 0 G17:00 | 23/11/20 | R 15 FK Ufa 1 FK Khimki 2 |
| 11 | |  RFK Akhmat Grozny | 20 | 7 | 5 | 8 | 20 | 23 | -3 | 26 | M16:30 | 28/02/21 | R 20 RFK Akhmat Grozny 1 FK Dinamo Moscow 2 B20:00 | 17/12/20 | R 19 RFK Akhmat Grozny 0 FK Rubin Kazan 0 M19:00 | 13/12/20 | R 18 RFK Akhmat Grozny 0 FC Rostov 1 M19:00 | 07/12/20 | R 17 PFK Sochi 2 RFK Akhmat Grozny 0 B19:00 | 28/11/20 | R 16 RFK Akhmat Grozny 0 FK Lokomotiv Moskova 0 B16:30 | 21/11/20 | R 15 RFK Akhmat Grozny 2 FK Zenit St Petersburg 2 |
| 12 | |  Ural Ekaterinburg | 20 | 4 | 10 | 6 | 18 | 25 | -7 | 22 | B19:00 | 28/02/21 | R 20 FC Krasnodar 2 Ural Ekaterinburg 2 B18:00 | 18/12/20 | R 19 FK Tambov 1 Ural Ekaterinburg 1 B19:00 | 13/12/20 | R 18 CSKA Moskova 2 Ural Ekaterinburg 2 M19:00 | 05/12/20 | R 17 FK Zenit St Petersburg 5 Ural Ekaterinburg 1 G12:00 | 29/11/20 | R 16 Ural Ekaterinburg 1 PFK Sochi 0 B16:30 | 22/11/20 | R 15 SK Rotor 0 Ural Ekaterinburg 0 |
| 13 | |  SK Rotor | 20 | 4 | 5 | 11 | 12 | 31 | -19 | 17 | G19:00 | 26/02/21 | R 20 FK Tambov 1 SK Rotor 3 G18:00 | 16/12/20 | R 19 SK Rotor 1 PFK Arsenal Tula 0 G14:00 | 12/12/20 | R 18 SK Rotor 1 FK Ufa 0 M19:00 | 05/12/20 | R 17 FC Krasnodar 5 SK Rotor 0 M19:00 | 29/11/20 | R 16 FK Spartak Moskova 2 SK Rotor 0 B16:30 | 22/11/20 | R 15 SK Rotor 0 Ural Ekaterinburg 0 |
| 14 | |  PFK Arsenal Tula | 20 | 3 | 5 | 12 | 17 | 34 | -17 | 14 | M19:00 | 27/02/21 | R 20 PFK Sochi 4 PFK Arsenal Tula 0 M18:00 | 16/12/20 | R 19 SK Rotor 1 PFK Arsenal Tula 0 M19:00 | 11/12/20 | R 18 FK Khimki 1 PFK Arsenal Tula 0 M16:30 | 06/12/20 | R 17 FK Dinamo Moscow 1 PFK Arsenal Tula 0 B14:00 | 28/11/20 | R 16 PFK Arsenal Tula 0 FK Zenit St Petersburg 0 M19:00 | 21/11/20 | R 15 FK Lokomotiv Moskova 1 PFK Arsenal Tula 0 |
| 15 | |  FK Ufa | 20 | 3 | 4 | 13 | 15 | 33 | -18 | 13 | M14:00 | 27/02/21 | R 20 FK Khimki 2 FK Ufa 1 M18:00 | 17/12/20 | R 19 FC Krasnodar 1 FK Ufa 0 M14:00 | 12/12/20 | R 18 SK Rotor 1 FK Ufa 0 G14:00 | 06/12/20 | R 17 FC Rostov 0 FK Ufa 1 G14:00 | 29/11/20 | R 16 FK Ufa 4 FK Tambov 0 M17:00 | 23/11/20 | R 15 FK Ufa 1 FK Khimki 2 |
| 16 | |  FK Tambov | 20 | 3 | 4 | 13 | 14 | 32 | -18 | 13 | M19:00 | 26/02/21 | R 20 FK Tambov 1 SK Rotor 3 B18:00 | 18/12/20 | R 19 FK Tambov 1 Ural Ekaterinburg 1 M14:00 | 13/12/20 | R 18 FK Tambov 0 FK Rubin Kazan 1 M16:30 | 05/12/20 | R 17 FK Spartak Moskova 5 FK Tambov 1 M14:00 | 29/11/20 | R 16 FK Ufa 4 FK Tambov 0 M14:00 | 21/11/20 | R 15 FC Krasnodar 1 FK Tambov 0 |
