| 1 | |  Avondale FC | 18 | 12 | 5 | 1 | 39 | 15 | 24 | 41 | G08:00 | 31/07/21 | R 23  Avondale FC 2 St Albans Saints SC 1 G08:00 | 11/07/21 | R 20 Eastern Lions SC 0 Avondale FC 4 G08:00 | 03/07/21 | R 19 Avondale FC 3 Bentleigh Greens 1 G12:30 | 25/06/21 | R 18 Melbourne Knights 0 Avondale FC 2 G08:00 | 19/06/21 | R 17 Avondale FC 3 Dandenong City SC 0 B08:00 | 23/05/21 | R 13 Heidelberg United 1 Avondale FC 1 |
| 2 | |  Oakleigh Cannons | 18 | 10 | 4 | 4 | 36 | 21 | 15 | 34 | G09:30 | 31/07/21 | R 23 Oakleigh Cannons 1 Port Melbourne Sharks 0 B12:30 | 09/07/21 | R 20 Melbourne Knights 1 Oakleigh Cannons 1 G13:30 | 02/07/21 | R 19 Oakleigh Cannons 6 Dandenong City SC 1 G13:00 | 25/06/21 | R 18 Green Gully Cavaliers 1 Oakleigh Cannons 3 G13:30 | 18/06/21 | R 17 Oakleigh Cannons 3 Altona Magic SC 2 M13:30 | 21/05/21 | R 13 Oakleigh Cannons 0 Hume City 2 |
| 3 | |  Bentleigh Greens | 18 | 10 | 3 | 5 | 31 | 22 | 9 | 33 | G13:00 | 30/07/21 | R 23 Green Gully Cavaliers 0 Bentleigh Greens 2 G08:00 | 11/07/21 | R 20 Heidelberg United 0 Bentleigh Greens 3 M08:00 | 03/07/21 | R 19 Avondale FC 3 Bentleigh Greens 1 M13:30 | 25/06/21 | R 18 Bentleigh Greens 0 Hume City 3 G08:00 | 20/06/21 | R 17 St Albans Saints SC 1 Bentleigh Greens 3 B12:00 | 22/05/21 | R 13 South Melbourne 1 Bentleigh Greens 1 |
| 4 | |  Hume City | 18 | 9 | 4 | 5 | 35 | 21 | 14 | 31 | B10:30 | 31/07/21 | R 23 Hume City 1 South Melbourne 1 G10:00 | 11/07/21 | R 20 Port Melbourne Sharks 0 Hume City 1 G10:30 | 03/07/21 | R 19 Hume City 4 Eastern Lions SC 0 G13:30 | 25/06/21 | R 18 Bentleigh Greens 0 Hume City 3 M10:30 | 19/06/21 | R 17 Hume City 2 Melbourne Knights 3 G13:30 | 21/05/21 | R 13 Oakleigh Cannons 0 Hume City 2 |
| 5 | |  Dandenong Thunder | 18 | 8 | 4 | 6 | 30 | 25 | 5 | 28 | G08:00 | 01/08/21 | R 23 Heidelberg United 0 Dandenong Thunder 1 G08:00 | 11/07/21 | R 20 St Albans Saints SC 0 Dandenong Thunder 1 G12:00 | 03/07/21 | R 19 Dandenong Thunder 4 South Melbourne 1 B12:45 | 25/06/21 | R 18 Port Melbourne Sharks 2 Dandenong Thunder 2 G12:00 | 19/06/21 | R 17 Dandenong Thunder 2 Eastern Lions SC 1 B13:00 | 21/05/21 | R 13 Green Gully Cavaliers 2 Dandenong Thunder 2 |
| 6 | |  Heidelberg United | 18 | 7 | 6 | 5 | 23 | 22 | 1 | 27 | M08:00 | 01/08/21 | R 23 Heidelberg United 0 Dandenong Thunder 1 M08:00 | 11/07/21 | R 20 Heidelberg United 0 Bentleigh Greens 3 B08:00 | 04/07/21 | R 19 Heidelberg United 2 Melbourne Knights 2 M13:30 | 25/06/21 | R 18 Dandenong City SC 4 Heidelberg United 3 G08:00 | 20/06/21 | R 17 Heidelberg United 1 Green Gully Cavaliers 0 B08:00 | 23/05/21 | R 13 Heidelberg United 1 Avondale FC 1 |
| 7 | |  Port Melbourne Sharks | 18 | 7 | 5 | 6 | 28 | 19 | 9 | 26 | M09:30 | 31/07/21 | R 23 Oakleigh Cannons 1 Port Melbourne Sharks 0 M10:00 | 11/07/21 | R 20 Port Melbourne Sharks 0 Hume City 1 G08:00 | 04/07/21 | R 19 St Albans Saints SC 0 Port Melbourne Sharks 4 B12:45 | 25/06/21 | R 18 Port Melbourne Sharks 2 Dandenong Thunder 2 G12:30 | 18/06/21 | R 17 South Melbourne 0 Port Melbourne Sharks 1 G13:30 | 21/05/21 | R 13 Dandenong City SC 0 Port Melbourne Sharks 2 |
| 8 | |  Melbourne Knights | 18 | 7 | 5 | 6 | 24 | 26 | -2 | 26 | M13:30 | 30/07/21 | R 23 Dandenong City SC 2 Melbourne Knights 0 B12:30 | 09/07/21 | R 20 Melbourne Knights 1 Oakleigh Cannons 1 B08:00 | 04/07/21 | R 19 Heidelberg United 2 Melbourne Knights 2 M12:30 | 25/06/21 | R 18 Melbourne Knights 0 Avondale FC 2 G10:30 | 19/06/21 | R 17 Hume City 2 Melbourne Knights 3 M12:30 | 21/05/21 | R 13 Melbourne Knights 1 Eastern Lions SC 2 |
| 9 | |  South Melbourne | 18 | 6 | 7 | 5 | 19 | 18 | 1 | 25 | B10:30 | 31/07/21 | R 23 Hume City 1 South Melbourne 1 B12:30 | 09/07/21 | R 20 South Melbourne 1 Green Gully Cavaliers 1 M12:00 | 03/07/21 | R 19 Dandenong Thunder 4 South Melbourne 1 M12:00 | 26/06/21 | R 18 South Melbourne 1 Altona Magic SC 2 M12:30 | 18/06/21 | R 17 South Melbourne 0 Port Melbourne Sharks 1 B12:00 | 22/05/21 | R 13 South Melbourne 1 Bentleigh Greens 1 |
| 10 | |  Green Gully Cavaliers | 18 | 5 | 5 | 8 | 23 | 25 | -2 | 20 | M13:00 | 30/07/21 | R 23 Green Gully Cavaliers 0 Bentleigh Greens 2 B12:30 | 09/07/21 | R 20 South Melbourne 1 Green Gully Cavaliers 1 G13:00 | 02/07/21 | R 19 Green Gully Cavaliers 4 Altona Magic SC 0 M13:00 | 25/06/21 | R 18 Green Gully Cavaliers 1 Oakleigh Cannons 3 M08:00 | 20/06/21 | R 17 Heidelberg United 1 Green Gully Cavaliers 0 B13:00 | 21/05/21 | R 13 Green Gully Cavaliers 2 Dandenong Thunder 2 |
| 11 | |  Eastern Lions SC | 18 | 4 | 3 | 11 | 18 | 34 | -16 | 15 | M11:30 | 31/07/21 | R 23 Altona Magic SC 2 Eastern Lions SC 1 M08:00 | 11/07/21 | R 20 Eastern Lions SC 0 Avondale FC 4 M10:30 | 03/07/21 | R 19 Hume City 4 Eastern Lions SC 0 G08:00 | 26/06/21 | R 18 Eastern Lions SC 2 St Albans Saints SC 1 M12:00 | 19/06/21 | R 17 Dandenong Thunder 2 Eastern Lions SC 1 G12:30 | 21/05/21 | R 13 Melbourne Knights 1 Eastern Lions SC 2 |
| 12 | |  Altona Magic SC | 18 | 2 | 8 | 8 | 19 | 32 | -13 | 14 | G11:30 | 31/07/21 | R 23 Altona Magic SC 2 Eastern Lions SC 1 B13:30 | 09/07/21 | R 20 Dandenong City SC 1 Altona Magic SC 1 M13:00 | 02/07/21 | R 19 Green Gully Cavaliers 4 Altona Magic SC 0 G12:00 | 26/06/21 | R 18 South Melbourne 1 Altona Magic SC 2 M13:30 | 18/06/21 | R 17 Oakleigh Cannons 3 Altona Magic SC 2 B11:30 | 22/05/21 | R 13 Altona Magic SC 1 St Albans Saints SC 1 |
| 13 | |  Dandenong City SC | 18 | 3 | 5 | 10 | 20 | 36 | -16 | 14 | G13:30 | 30/07/21 | R 23 Dandenong City SC 2 Melbourne Knights 0 B13:30 | 09/07/21 | R 20 Dandenong City SC 1 Altona Magic SC 1 M13:30 | 02/07/21 | R 19 Oakleigh Cannons 6 Dandenong City SC 1 G13:30 | 25/06/21 | R 18 Dandenong City SC 4 Heidelberg United 3 M08:00 | 19/06/21 | R 17 Avondale FC 3 Dandenong City SC 0 M13:30 | 21/05/21 | R 13 Dandenong City SC 0 Port Melbourne Sharks 2 |
| 14 | |  St Albans Saints SC | 18 | 2 | 4 | 12 | 10 | 39 | -29 | 10 | M08:00 | 31/07/21 | R 23 Avondale FC 2 St Albans Saints SC 1 M08:00 | 11/07/21 | R 20 St Albans Saints SC 0 Dandenong Thunder 1 M08:00 | 04/07/21 | R 19 St Albans Saints SC 0 Port Melbourne Sharks 4 M08:00 | 26/06/21 | R 18 Eastern Lions SC 2 St Albans Saints SC 1 M08:00 | 20/06/21 | R 17 St Albans Saints SC 1 Bentleigh Greens 3 B11:30 | 22/05/21 | R 13 Altona Magic SC 1 St Albans Saints SC 1 |
