| 1 | |  CF Monterrey | 17 | 14 | 1 | 2 | 51 | 13 | 38 | 43 | M03:00 | 03/05/22 | R 17  CD Guadalajara 1 CF Monterrey 0 B05:00 | 26/04/22 | R 16 CF Monterrey 0 CF Tigres UANL 0 |
| 2 | |  CD Guadalajara | 17 | 13 | 4 | 0 | 27 | 6 | 21 | 43 | G03:00 | 03/05/22 | R 17 CD Guadalajara 1 CF Monterrey 0 |
| 3 | |  CF Tigres UANL | 17 | 11 | 6 | 0 | 43 | 11 | 32 | 39 | B02:00 | 02/05/22 | R 17 CF Tigres UANL 1 Club America 1 B05:00 | 26/04/22 | R 16 CF Monterrey 0 CF Tigres UANL 0 |
| 4 | |  Club America | 17 | 11 | 4 | 2 | 41 | 14 | 27 | 37 | B02:00 | 02/05/22 | R 17 CF Tigres UANL 1 Club America 1 G03:00 | 26/04/22 | R 16 Club America 4 CF Pachuca 0 B05:00 | 19/04/22 | R 15 Club Tijuana de Caliente 2 Club America 2 G03:00 | 12/04/22 | R 9 Club Santos Laguna 0 Club America 3 |
| 5 | |  CF Pachuca | 17 | 9 | 3 | 5 | 28 | 22 | 6 | 30 | B03:00 | 01/05/22 | R 17 CF Pachuca 1 Club Necaxa 1 |
| 6 | |  Atlas FC | 17 | 7 | 6 | 4 | 27 | 25 | 2 | 27 | G20:00 | 02/05/22 | R 17 Atlas FC 2 Club Leon 1 M20:00 | 23/04/22 | R 16 Atlas FC 0 CD Guadalajara 1 B03:00 | 19/04/22 | R 15 CF Pachuca 2 Atlas FC 2 G01:00 | 08/04/22 | R 10 Queretaro FC 1 Atlas FC 3 |
| 7 | |  Pumas Unam | 17 | 6 | 4 | 7 | 18 | 17 | 1 | 22 | G01:00 | 03/05/22 | R 17 Deportivo Toluca FC 2 Pumas Unam 3 G20:00 | 23/04/22 | R 16 Pumas Unam 2 Atletico San Luis 1 M01:00 | 19/04/22 | R 15 CD Guadalajara 2 Pumas Unam 1 M21:00 | 02/04/22 | R 14 Pumas Unam 0 CF Tigres UANL 1 |
| 8 | |  Club Tijuana de Caliente | 17 | 4 | 9 | 4 | 24 | 29 | -5 | 21 | G05:00 | 03/05/22 | R 17 Club Tijuana de Caliente 3 FC Juarez 2 M03:00 | 25/04/22 | R 16 Mazatlan FC 2 Club Tijuana de Caliente 1 B05:00 | 19/04/22 | R 15 Club Tijuana de Caliente 2 Club America 2 G02:00 | 02/04/22 | R 14 Queretaro FC 0 Club Tijuana de Caliente 2 |
| 9 | |  Cruz Azul | 17 | 6 | 3 | 8 | 22 | 30 | -8 | 21 | G20:00 | 30/04/22 | R 17 Cruz Azul 3 Puebla FC 1 G01:00 | 23/04/22 | R 16 Club Necaxa 1 Cruz Azul 2 M20:00 | 16/04/22 | R 15 Cruz Azul 1 CF Monterrey 3 M01:00 | 12/04/22 | R 9 Deportivo Toluca FC 3 Cruz Azul 1 G06:00 | 01/04/22 | R 14 Club Leon 2 Cruz Azul 3 G21:00 | 26/03/22 | R 13 Cruz Azul 2 Atlas FC 1 |
| 10 | |  Deportivo Toluca FC | 17 | 5 | 5 | 7 | 29 | 32 | -3 | 20 | M01:00 | 03/05/22 | R 17 Deportivo Toluca FC 2 Pumas Unam 3 B03:00 | 26/04/22 | R 16 Club Leon 2 Deportivo Toluca FC 2 G01:00 | 19/04/22 | R 15 Deportivo Toluca FC 2 Mazatlan FC 0 G01:00 | 12/04/22 | R 9 Deportivo Toluca FC 3 Cruz Azul 1 M21:00 | 02/04/22 | R 14 Atlas FC 3 Deportivo Toluca FC 2 G01:00 | 29/03/22 | R 13 Deportivo Toluca FC 3 Queretaro FC 0 |
| 11 | |  Atletico San Luis | 17 | 5 | 5 | 7 | 23 | 29 | -6 | 20 | G01:00 | 30/04/22 | R 17 Atletico San Luis 3 Queretaro FC 1 M20:00 | 23/04/22 | R 16 Pumas Unam 2 Atletico San Luis 1 G01:00 | 17/04/22 | R 15 Atletico San Luis 4 Club Leon 0 G01:00 | 12/04/22 | R 9 Atletico San Luis 3 Puebla FC 1 G01:00 | 01/04/22 | R 14 Club Necaxa 1 Atletico San Luis 2 M02:00 | 28/03/22 | R 13 Atletico San Luis 0 CF Tigres UANL 6 |
| 12 | |  Queretaro FC | 17 | 5 | 3 | 9 | 16 | 29 | -13 | 18 | M01:00 | 30/04/22 | R 17 Atletico San Luis 3 Queretaro FC 1 G01:00 | 23/04/22 | R 16 Queretaro FC 1 Puebla FC 0 M02:00 | 18/04/22 | R 15 FC Juarez 2 Queretaro FC 1 B05:00 | 15/04/22 | R 9 CF Tigres UANL 0 Queretaro FC 0 M01:00 | 08/04/22 | R 10 Queretaro FC 1 Atlas FC 3 M02:00 | 02/04/22 | R 14 Queretaro FC 0 Club Tijuana de Caliente 2 |
| 13 | |  Club Santos Laguna | 17 | 5 | 2 | 10 | 17 | 29 | -12 | 17 | G03:00 | 03/05/22 | R 17 Club Santos Laguna 1 Mazatlan FC 0 G03:00 | 26/04/22 | R 16 Club Santos Laguna 3 FC Juarez 1 M03:00 | 19/04/22 | R 15 CF Tigres UANL 4 Club Santos Laguna 1 M03:00 | 12/04/22 | R 9 Club Santos Laguna 0 Club America 3 B06:00 | 01/04/22 | R 14 Club Santos Laguna 0 Puebla FC 0 M19:00 | 27/03/22 | R 13 CF Monterrey 3 Club Santos Laguna 1 |
| 14 | |  Club Necaxa | 17 | 3 | 6 | 8 | 17 | 31 | -14 | 15 | B03:00 | 01/05/22 | R 17 CF Pachuca 1 Club Necaxa 1 M01:00 | 23/04/22 | R 16 Club Necaxa 1 Cruz Azul 2 G20:00 | 17/04/22 | R 15 Puebla FC 0 Club Necaxa 1 M01:00 | 01/04/22 | R 14 Club Necaxa 1 Atletico San Luis 2 B06:00 | 29/03/22 | R 13 Club Tijuana de Caliente 1 Club Necaxa 1 M02:00 | 21/03/22 | R 12 Queretaro FC 3 Club Necaxa 0 |
| 15 | |  Mazatlan FC | 17 | 3 | 4 | 10 | 11 | 30 | -19 | 13 | M03:00 | 03/05/22 | R 17 Club Santos Laguna 1 Mazatlan FC 0 G03:00 | 25/04/22 | R 16 Mazatlan FC 2 Club Tijuana de Caliente 1 M01:00 | 19/04/22 | R 15 Deportivo Toluca FC 2 Mazatlan FC 0 M03:00 | 04/04/22 | R 14 Mazatlan FC 0 CD Guadalajara 1 M04:00 | 29/03/22 | R 13 CF Pachuca 5 Mazatlan FC 0 M05:00 | 22/03/22 | R 12 Mazatlan FC 0 Pumas Unam 2 |
| 16 | |  Club Leon | 17 | 3 | 4 | 10 | 18 | 40 | -22 | 13 | M20:00 | 02/05/22 | R 17 Atlas FC 2 Club Leon 1 B03:00 | 26/04/22 | R 16 Club Leon 2 Deportivo Toluca FC 2 M01:00 | 17/04/22 | R 15 Atletico San Luis 4 Club Leon 0 M03:00 | 11/04/22 | R 9 Club Leon 1 CF Monterrey 6 M06:00 | 01/04/22 | R 14 Club Leon 2 Cruz Azul 3 M06:00 | 29/03/22 | R 13 Club Leon 0 CD Guadalajara 2 |
| 17 | |  Puebla FC | 17 | 3 | 3 | 11 | 11 | 25 | -14 | 12 | M20:00 | 30/04/22 | R 17 Cruz Azul 3 Puebla FC 1 M01:00 | 23/04/22 | R 16 Queretaro FC 1 Puebla FC 0 M20:00 | 17/04/22 | R 15 Puebla FC 0 Club Necaxa 1 M01:00 | 12/04/22 | R 9 Atletico San Luis 3 Puebla FC 1 B06:00 | 01/04/22 | R 14 Club Santos Laguna 0 Puebla FC 0 B21:00 | 27/03/22 | R 13 Puebla FC 1 Club America 1 |
| 18 | |  FC Juarez | 17 | 3 | 2 | 12 | 18 | 29 | -11 | 11 | M05:00 | 03/05/22 | R 17 Club Tijuana de Caliente 3 FC Juarez 2 M03:00 | 26/04/22 | R 16 Club Santos Laguna 3 FC Juarez 1 G02:00 | 18/04/22 | R 15 FC Juarez 2 Queretaro FC 1 B01:00 | 12/04/22 | R 9 CD Guadalajara 0 FC Juarez 0 M00:45 | 02/04/22 | R 14 Club America 2 FC Juarez 1 G04:00 | 27/03/22 | R 13 FC Juarez 1 Pumas Unam 0 |
