| 1 | |  Real Madrid | 5 | 4 | 1 | 0 | 15 | 7 | 8 | 13 | G22:00 | 19/09/21 | R 5  Valencia 1 Real Madrid 2 G22:00 | 12/09/21 | R 4 Real Madrid 5 Celta de Vigo 2 G23:00 | 28/08/21 | R 3 Real Betis Sevilla 0 Real Madrid 1 B23:00 | 22/08/21 | R 2 Levante 3 Real Madrid 3 G23:00 | 14/08/21 | R 1 Alaves 1 Real Madrid 4 |
| 2 | |  Atletico Madrid | 5 | 3 | 2 | 0 | 7 | 4 | 3 | 11 | B17:15 | 18/09/21 | R 5 Atletico Madrid 0 Athletic de Bilbao 0 G15:00 | 12/09/21 | R 4 Espanyol Barcelona 1 Atletico Madrid 2 B23:00 | 29/08/21 | R 3 Atletico Madrid 2 Villarreal 2 G20:30 | 22/08/21 | R 2 Atletico Madrid 1 Elche 0 G18:30 | 15/08/21 | R 1 Celta de Vigo 1 Atletico Madrid 2 |
| 3 | |  Valencia | 5 | 3 | 1 | 1 | 10 | 4 | 6 | 10 | M22:00 | 19/09/21 | R 5 Valencia 1 Real Madrid 2 G17:15 | 12/09/21 | R 4 CA Osasuna 1 Valencia 4 G23:15 | 27/08/21 | R 3 Valencia 3 Alaves 0 B20:30 | 21/08/21 | R 2 Granada 1 Valencia 1 G22:00 | 13/08/21 | R 1 Valencia 1 Getafe 0 |
| 4 | |  Real Sociedad San Sebastian | 5 | 3 | 1 | 1 | 6 | 4 | 2 | 10 | B17:15 | 19/09/21 | R 5 Real Sociedad San Sebastian 0 Sevilla 0 G19:30 | 12/09/21 | R 4 Cadiz 0 Real Sociedad San Sebastian 2 G20:30 | 28/08/21 | R 3 Real Sociedad San Sebastian 1 Levante 0 G18:00 | 22/08/21 | R 2 Real Sociedad San Sebastian 1 Rayo Vallecano 0 M21:00 | 15/08/21 | R 1 Barcelona 4 Real Sociedad San Sebastian 2 |
| 5 | |  Athletic de Bilbao | 5 | 2 | 3 | 0 | 4 | 1 | 3 | 9 | B17:15 | 18/09/21 | R 5 Atletico Madrid 0 Athletic de Bilbao 0 G22:00 | 11/09/21 | R 4 Athletic de Bilbao 2 RCD Mallorca 0 G18:00 | 28/08/21 | R 3 Celta de Vigo 0 Athletic de Bilbao 1 B23:00 | 21/08/21 | R 2 Athletic de Bilbao 1 Barcelona 1 B23:00 | 16/08/21 | R 1 Elche 0 Athletic de Bilbao 0 |
| 6 | |  Sevilla | 4 | 2 | 2 | 0 | 5 | 1 | 4 | 8 | B17:15 | 19/09/21 | R 5 Real Sociedad San Sebastian 0 Sevilla 0 B20:30 | 28/08/21 | R 3 Elche 1 Sevilla 1 G21:00 | 23/08/21 | R 2 Getafe 0 Sevilla 1 G23:15 | 15/08/21 | R 1 Sevilla 3 Rayo Vallecano 0 |
| 7 | |  CA Osasuna | 5 | 2 | 2 | 1 | 6 | 6 | 0 | 8 | G22:00 | 18/09/21 | R 5 Alaves 0 CA Osasuna 2 M17:15 | 12/09/21 | R 4 CA Osasuna 1 Valencia 4 G20:30 | 29/08/21 | R 3 Cadiz 2 CA Osasuna 3 B23:00 | 23/08/21 | R 2 CA Osasuna 0 Celta de Vigo 0 B23:00 | 14/08/21 | R 1 CA Osasuna 0 Espanyol Barcelona 0 |
| 8 | |  RCD Mallorca | 5 | 2 | 2 | 1 | 3 | 3 | 0 | 8 | B15:00 | 19/09/21 | R 5 RCD Mallorca 0 Villarreal 0 M22:00 | 11/09/21 | R 4 Athletic de Bilbao 2 RCD Mallorca 0 G21:00 | 27/08/21 | R 3 RCD Mallorca 1 Espanyol Barcelona 0 G18:00 | 21/08/21 | R 2 Alaves 0 RCD Mallorca 1 B20:30 | 14/08/21 | R 1 RCD Mallorca 1 Real Betis Sevilla 1 |
| 9 | |  Rayo Vallecano | 5 | 2 | 1 | 2 | 8 | 5 | 3 | 7 | G15:00 | 18/09/21 | R 5 Rayo Vallecano 3 Getafe 0 B19:30 | 11/09/21 | R 4 Levante 1 Rayo Vallecano 1 G20:30 | 29/08/21 | R 3 Rayo Vallecano 4 Granada 0 M18:00 | 22/08/21 | R 2 Real Sociedad San Sebastian 1 Rayo Vallecano 0 M23:15 | 15/08/21 | R 1 Sevilla 3 Rayo Vallecano 0 |
| 10 | |  Barcelona | 3 | 2 | 1 | 0 | 7 | 4 | 3 | 7 | G18:00 | 29/08/21 | R 3 Barcelona 2 Getafe 1 B23:00 | 21/08/21 | R 2 Athletic de Bilbao 1 Barcelona 1 G21:00 | 15/08/21 | R 1 Barcelona 4 Real Sociedad San Sebastian 2 |
| 11 | |  Real Betis Sevilla | 5 | 1 | 3 | 1 | 6 | 6 | 0 | 6 | B19:30 | 19/09/21 | R 5 Real Betis Sevilla 2 Espanyol Barcelona 2 G23:00 | 13/09/21 | R 4 Granada 1 Real Betis Sevilla 2 M23:00 | 28/08/21 | R 3 Real Betis Sevilla 0 Real Madrid 1 B22:00 | 20/08/21 | R 2 Real Betis Sevilla 1 Cadiz 1 B20:30 | 14/08/21 | R 1 RCD Mallorca 1 Real Betis Sevilla 1 |
| 12 | |  Elche | 5 | 1 | 3 | 1 | 3 | 3 | 0 | 6 | B19:30 | 18/09/21 | R 5 Elche 1 Levante 1 G21:00 | 13/09/21 | R 4 Getafe 0 Elche 1 B20:30 | 28/08/21 | R 3 Elche 1 Sevilla 1 M20:30 | 22/08/21 | R 2 Atletico Madrid 1 Elche 0 B23:00 | 16/08/21 | R 1 Elche 0 Athletic de Bilbao 0 |
| 13 | |  Cadiz | 5 | 1 | 2 | 2 | 6 | 8 | -2 | 5 | G22:00 | 17/09/21 | R 5 Celta de Vigo 1 Cadiz 2 M19:30 | 12/09/21 | R 4 Cadiz 0 Real Sociedad San Sebastian 2 M20:30 | 29/08/21 | R 3 Cadiz 2 CA Osasuna 3 B22:00 | 20/08/21 | R 2 Real Betis Sevilla 1 Cadiz 1 B20:30 | 14/08/21 | R 1 Cadiz 1 Levante 1 |
| 14 | |  Villarreal | 4 | 0 | 4 | 0 | 2 | 2 | 0 | 4 | B15:00 | 19/09/21 | R 5 RCD Mallorca 0 Villarreal 0 B23:00 | 29/08/21 | R 3 Atletico Madrid 2 Villarreal 2 B20:30 | 21/08/21 | R 2 Espanyol Barcelona 0 Villarreal 0 B21:00 | 16/08/21 | R 1 Villarreal 0 Granada 0 |
| 15 | |  Levante | 5 | 0 | 4 | 1 | 6 | 7 | -1 | 4 | B19:30 | 18/09/21 | R 5 Elche 1 Levante 1 B19:30 | 11/09/21 | R 4 Levante 1 Rayo Vallecano 1 M20:30 | 28/08/21 | R 3 Real Sociedad San Sebastian 1 Levante 0 B23:00 | 22/08/21 | R 2 Levante 3 Real Madrid 3 B20:30 | 14/08/21 | R 1 Cadiz 1 Levante 1 |
| 16 | |  Espanyol Barcelona | 5 | 0 | 3 | 2 | 3 | 5 | -2 | 3 | B19:30 | 19/09/21 | R 5 Real Betis Sevilla 2 Espanyol Barcelona 2 M15:00 | 12/09/21 | R 4 Espanyol Barcelona 1 Atletico Madrid 2 M21:00 | 27/08/21 | R 3 RCD Mallorca 1 Espanyol Barcelona 0 B20:30 | 21/08/21 | R 2 Espanyol Barcelona 0 Villarreal 0 B23:00 | 14/08/21 | R 1 CA Osasuna 0 Espanyol Barcelona 0 |
| 17 | |  Granada | 4 | 0 | 2 | 2 | 2 | 7 | -5 | 2 | M23:00 | 13/09/21 | R 4 Granada 1 Real Betis Sevilla 2 M20:30 | 29/08/21 | R 3 Rayo Vallecano 4 Granada 0 B20:30 | 21/08/21 | R 2 Granada 1 Valencia 1 B21:00 | 16/08/21 | R 1 Villarreal 0 Granada 0 |
| 18 | |  Celta de Vigo | 5 | 0 | 1 | 4 | 4 | 10 | -6 | 1 | M22:00 | 17/09/21 | R 5 Celta de Vigo 1 Cadiz 2 M22:00 | 12/09/21 | R 4 Real Madrid 5 Celta de Vigo 2 M18:00 | 28/08/21 | R 3 Celta de Vigo 0 Athletic de Bilbao 1 B23:00 | 23/08/21 | R 2 CA Osasuna 0 Celta de Vigo 0 M18:30 | 15/08/21 | R 1 Celta de Vigo 1 Atletico Madrid 2 |
| 19 | |  Getafe | 5 | 0 | 0 | 5 | 1 | 8 | -7 | 0 | M15:00 | 18/09/21 | R 5 Rayo Vallecano 3 Getafe 0 M21:00 | 13/09/21 | R 4 Getafe 0 Elche 1 M18:00 | 29/08/21 | R 3 Barcelona 2 Getafe 1 M21:00 | 23/08/21 | R 2 Getafe 0 Sevilla 1 M22:00 | 13/08/21 | R 1 Valencia 1 Getafe 0 |
| 20 | |  Alaves | 4 | 0 | 0 | 4 | 1 | 10 | -9 | 0 | M22:00 | 18/09/21 | R 5 Alaves 0 CA Osasuna 2 M23:15 | 27/08/21 | R 3 Valencia 3 Alaves 0 M18:00 | 21/08/21 | R 2 Alaves 0 RCD Mallorca 1 M23:00 | 14/08/21 | R 1 Alaves 1 Real Madrid 4 |
