| 1 | |  Real Madrid | 38 | 26 | 8 | 4 | 80 | 31 | 49 | 86 | B22:00 | 20/05/22 | R 38  Real Madrid 0 Real Betis Sevilla 0 B20:30 | 15/05/22 | R 37 Cadiz 1 Real Madrid 1 G22:30 | 12/05/22 | R 36 Real Madrid 6 Levante 0 M22:00 | 08/05/22 | R 35 Atletico Madrid 1 Real Madrid 0 G17:15 | 30/04/22 | R 34 Real Madrid 4 Espanyol Barcelona 0 G22:30 | 20/04/22 | R 33 CA Osasuna 1 Real Madrid 3 |
| 2 | |  Barcelona | 37 | 21 | 10 | 6 | 68 | 36 | 32 | 73 | B20:30 | 15/05/22 | R 37 Getafe 0 Barcelona 0 G22:30 | 10/05/22 | R 36 Barcelona 3 Celta de Vigo 1 G22:00 | 07/05/22 | R 35 Real Betis Sevilla 1 Barcelona 2 G22:00 | 01/05/22 | R 34 Barcelona 2 RCD Mallorca 1 M22:00 | 24/04/22 | R 21 Barcelona 0 Rayo Vallecano 1 G22:30 | 21/04/22 | R 33 Real Sociedad San Sebastian 0 Barcelona 1 |
| 3 | |  Atletico Madrid | 37 | 20 | 8 | 9 | 63 | 42 | 21 | 68 | B20:30 | 15/05/22 | R 37 Atletico Madrid 1 Sevilla 1 G22:30 | 11/05/22 | R 36 Elche 0 Atletico Madrid 2 G22:00 | 08/05/22 | R 35 Atletico Madrid 1 Real Madrid 0 M22:00 | 30/04/22 | R 34 Athletic de Bilbao 2 Atletico Madrid 0 B20:00 | 20/04/22 | R 33 Atletico Madrid 0 Granada 0 G17:15 | 17/04/22 | R 32 Atletico Madrid 2 Espanyol Barcelona 1 |
| 4 | |  Sevilla | 37 | 17 | 16 | 4 | 52 | 30 | 22 | 67 | B20:30 | 15/05/22 | R 37 Atletico Madrid 1 Sevilla 1 B21:30 | 11/05/22 | R 36 Sevilla 0 RCD Mallorca 0 B17:15 | 08/05/22 | R 35 Villarreal 1 Sevilla 1 B22:00 | 29/04/22 | R 34 Sevilla 1 Cadiz 1 G20:00 | 21/04/22 | R 33 Levante 2 Sevilla 3 M22:00 | 17/04/22 | R 32 Sevilla 2 Real Madrid 3 |
| 5 | |  Real Betis Sevilla | 38 | 19 | 8 | 11 | 62 | 40 | 22 | 65 | B22:00 | 20/05/22 | R 38 Real Madrid 0 Real Betis Sevilla 0 G20:30 | 15/05/22 | R 37 Real Betis Sevilla 2 Granada 0 G20:00 | 10/05/22 | R 36 Valencia 0 Real Betis Sevilla 3 M22:00 | 07/05/22 | R 35 Real Betis Sevilla 1 Barcelona 2 B22:00 | 02/05/22 | R 34 Getafe 0 Real Betis Sevilla 0 M22:00 | 19/04/22 | R 33 Real Betis Sevilla 0 Elche 1 |
| 6 | |  Real Sociedad San Sebastian | 37 | 17 | 11 | 9 | 39 | 35 | 4 | 62 | G20:30 | 15/05/22 | R 37 Villarreal 1 Real Sociedad San Sebastian 2 G20:00 | 12/05/22 | R 36 Real Sociedad San Sebastian 3 Cadiz 0 M22:00 | 06/05/22 | R 35 Levante 2 Real Sociedad San Sebastian 1 B19:30 | 01/05/22 | R 34 Rayo Vallecano 1 Real Sociedad San Sebastian 1 M22:30 | 21/04/22 | R 33 Real Sociedad San Sebastian 0 Barcelona 1 B22:00 | 15/04/22 | R 32 Real Sociedad San Sebastian 0 Real Betis Sevilla 0 |
| 7 | |  Villarreal | 37 | 15 | 11 | 11 | 61 | 37 | 24 | 56 | M20:30 | 15/05/22 | R 37 Villarreal 1 Real Sociedad San Sebastian 2 G21:00 | 12/05/22 | R 36 Rayo Vallecano 1 Villarreal 5 B17:15 | 08/05/22 | R 35 Villarreal 1 Sevilla 1 M15:00 | 30/04/22 | R 34 Alaves 2 Villarreal 1 G22:30 | 19/04/22 | R 33 Villarreal 2 Valencia 0 G22:00 | 16/04/22 | R 32 Getafe 1 Villarreal 2 |
| 8 | |  Athletic de Bilbao | 37 | 14 | 13 | 10 | 43 | 35 | 8 | 55 | G20:30 | 15/05/22 | R 37 Athletic de Bilbao 2 CA Osasuna 0 M21:00 | 10/05/22 | R 36 Granada 1 Athletic de Bilbao 0 B17:15 | 07/05/22 | R 35 Athletic de Bilbao 0 Valencia 0 G22:00 | 30/04/22 | R 34 Athletic de Bilbao 2 Atletico Madrid 0 G21:00 | 21/04/22 | R 33 Cadiz 2 Athletic de Bilbao 3 M19:30 | 17/04/22 | R 32 Athletic de Bilbao 0 Celta de Vigo 2 |
| 9 | |  CA Osasuna | 37 | 12 | 11 | 14 | 37 | 49 | -12 | 47 | M20:30 | 15/05/22 | R 37 Athletic de Bilbao 2 CA Osasuna 0 B20:00 | 11/05/22 | R 36 CA Osasuna 1 Getafe 1 B19:30 | 08/05/22 | R 35 Espanyol Barcelona 1 CA Osasuna 1 B15:00 | 01/05/22 | R 34 Elche 1 CA Osasuna 1 M22:30 | 20/04/22 | R 33 CA Osasuna 1 Real Madrid 3 G19:30 | 16/04/22 | R 32 Valencia 1 CA Osasuna 2 |
| 10 | |  Celta de Vigo | 37 | 12 | 10 | 15 | 43 | 41 | 2 | 46 | G20:30 | 15/05/22 | R 37 Celta de Vigo 1 Elche 0 M22:30 | 10/05/22 | R 36 Barcelona 3 Celta de Vigo 1 G19:30 | 07/05/22 | R 35 Celta de Vigo 4 Alaves 0 B17:15 | 01/05/22 | R 34 Granada 1 Celta de Vigo 1 M21:00 | 20/04/22 | R 33 Celta de Vigo 0 Getafe 2 G19:30 | 17/04/22 | R 32 Athletic de Bilbao 0 Celta de Vigo 2 |
| 11 | |  Valencia | 37 | 10 | 15 | 12 | 46 | 53 | -7 | 45 | B19:30 | 14/05/22 | R 37 Espanyol Barcelona 1 Valencia 1 M20:00 | 10/05/22 | R 36 Valencia 0 Real Betis Sevilla 3 B17:15 | 07/05/22 | R 35 Athletic de Bilbao 0 Valencia 0 B19:30 | 30/04/22 | R 34 Valencia 1 Levante 1 M22:30 | 19/04/22 | R 33 Villarreal 2 Valencia 0 M19:30 | 16/04/22 | R 32 Valencia 1 CA Osasuna 2 |
| 12 | |  Rayo Vallecano | 38 | 11 | 9 | 18 | 39 | 50 | -11 | 42 | M22:00 | 20/05/22 | R 38 Rayo Vallecano 2 Levante 4 M20:30 | 15/05/22 | R 37 RCD Mallorca 2 Rayo Vallecano 1 M21:00 | 12/05/22 | R 36 Rayo Vallecano 1 Villarreal 5 B15:00 | 08/05/22 | R 35 Getafe 0 Rayo Vallecano 0 B19:30 | 01/05/22 | R 34 Rayo Vallecano 1 Real Sociedad San Sebastian 1 G22:00 | 24/04/22 | R 21 Barcelona 0 Rayo Vallecano 1 |
| 13 | |  Espanyol Barcelona | 37 | 10 | 11 | 16 | 40 | 53 | -13 | 41 | B19:30 | 14/05/22 | R 37 Espanyol Barcelona 1 Valencia 1 M20:00 | 11/05/22 | R 36 Alaves 2 Espanyol Barcelona 1 B19:30 | 08/05/22 | R 35 Espanyol Barcelona 1 CA Osasuna 1 M17:15 | 30/04/22 | R 34 Real Madrid 4 Espanyol Barcelona 0 M20:00 | 21/04/22 | R 33 Espanyol Barcelona 0 Rayo Vallecano 1 M17:15 | 17/04/22 | R 32 Atletico Madrid 2 Espanyol Barcelona 1 |
| 14 | |  Getafe | 37 | 8 | 15 | 14 | 32 | 38 | -6 | 39 | B20:30 | 15/05/22 | R 37 Getafe 0 Barcelona 0 B20:00 | 11/05/22 | R 36 CA Osasuna 1 Getafe 1 B15:00 | 08/05/22 | R 35 Getafe 0 Rayo Vallecano 0 B22:00 | 02/05/22 | R 34 Getafe 0 Real Betis Sevilla 0 G21:00 | 20/04/22 | R 33 Celta de Vigo 0 Getafe 2 M22:00 | 16/04/22 | R 32 Getafe 1 Villarreal 2 |
| 15 | |  Elche | 37 | 10 | 9 | 18 | 37 | 51 | -14 | 39 | M20:30 | 15/05/22 | R 37 Celta de Vigo 1 Elche 0 M22:30 | 11/05/22 | R 36 Elche 0 Atletico Madrid 2 M19:30 | 07/05/22 | R 35 Cadiz 3 Elche 0 B15:00 | 01/05/22 | R 34 Elche 1 CA Osasuna 1 G22:00 | 19/04/22 | R 33 Real Betis Sevilla 0 Elche 1 G15:00 | 16/04/22 | R 32 Elche 3 RCD Mallorca 0 |
| 16 | |  Granada | 37 | 8 | 13 | 16 | 44 | 61 | -17 | 37 | M20:30 | 15/05/22 | R 37 Real Betis Sevilla 2 Granada 0 G21:00 | 10/05/22 | R 36 Granada 1 Athletic de Bilbao 0 G15:00 | 07/05/22 | R 35 RCD Mallorca 2 Granada 6 B17:15 | 01/05/22 | R 34 Granada 1 Celta de Vigo 1 B20:00 | 20/04/22 | R 33 Atletico Madrid 0 Granada 0 M15:00 | 17/04/22 | R 32 Granada 1 Levante 4 |
| 17 | |  RCD Mallorca | 37 | 9 | 9 | 19 | 34 | 63 | -29 | 36 | G20:30 | 15/05/22 | R 37 RCD Mallorca 2 Rayo Vallecano 1 B21:30 | 11/05/22 | R 36 Sevilla 0 RCD Mallorca 0 M15:00 | 07/05/22 | R 35 RCD Mallorca 2 Granada 6 M22:00 | 01/05/22 | R 34 Barcelona 2 RCD Mallorca 1 G20:00 | 19/04/22 | R 33 RCD Mallorca 2 Alaves 1 M15:00 | 16/04/22 | R 32 Elche 3 RCD Mallorca 0 |
| 18 | |  Cadiz | 37 | 7 | 15 | 15 | 34 | 51 | -17 | 36 | B20:30 | 15/05/22 | R 37 Cadiz 1 Real Madrid 1 M20:00 | 12/05/22 | R 36 Real Sociedad San Sebastian 3 Cadiz 0 G19:30 | 07/05/22 | R 35 Cadiz 3 Elche 0 B22:00 | 29/04/22 | R 34 Sevilla 1 Cadiz 1 M21:00 | 21/04/22 | R 33 Cadiz 2 Athletic de Bilbao 3 G22:00 | 18/04/22 | R 32 Barcelona 0 Cadiz 1 |
| 19 | |  Levante | 38 | 8 | 11 | 19 | 51 | 76 | -25 | 35 | G22:00 | 20/05/22 | R 38 Rayo Vallecano 2 Levante 4 G20:30 | 15/05/22 | R 37 Levante 3 Alaves 1 M22:30 | 12/05/22 | R 36 Real Madrid 6 Levante 0 G22:00 | 06/05/22 | R 35 Levante 2 Real Sociedad San Sebastian 1 B19:30 | 30/04/22 | R 34 Valencia 1 Levante 1 M20:00 | 21/04/22 | R 33 Levante 2 Sevilla 3 |
| 20 | |  Alaves | 37 | 8 | 7 | 22 | 31 | 64 | -33 | 31 | M20:30 | 15/05/22 | R 37 Levante 3 Alaves 1 G20:00 | 11/05/22 | R 36 Alaves 2 Espanyol Barcelona 1 M19:30 | 07/05/22 | R 35 Celta de Vigo 4 Alaves 0 G15:00 | 30/04/22 | R 34 Alaves 2 Villarreal 1 M20:00 | 19/04/22 | R 33 RCD Mallorca 2 Alaves 1 G17:15 | 16/04/22 | R 32 Alaves 1 Rayo Vallecano 0 |
