| 1 | |  Atletico Madrid | 38 | 26 | 8 | 4 | 67 | 25 | 42 | 86 | G19:00 | 22/05/21 | R 38  Real Valladolid 1 Atletico Madrid 2 G19:30 | 16/05/21 | R 37 Atletico Madrid 2 CA Osasuna 1 G23:00 | 12/05/21 | R 36 Atletico Madrid 2 Real Sociedad 1 B17:15 | 08/05/21 | R 35 Barcelona 0 Atletico Madrid 0 G17:15 | 01/05/21 | R 34 Elche 0 Atletico Madrid 1 M22:00 | 25/04/21 | R 32 Athletic de Bilbao 2 Atletico Madrid 1 |
| 2 | |  Real Madrid | 38 | 25 | 9 | 4 | 67 | 28 | 39 | 84 | G19:00 | 22/05/21 | R 38 Real Madrid 2 Villarreal 1 G19:30 | 16/05/21 | R 37 Athletic de Bilbao 0 Real Madrid 1 G23:00 | 13/05/21 | R 36 Granada 1 Real Madrid 4 B22:00 | 09/05/21 | R 35 Real Madrid 2 Sevilla 2 G22:00 | 01/05/21 | R 34 Real Madrid 2 CA Osasuna 0 B22:00 | 24/04/21 | R 32 Real Madrid 0 Real Betis Balompie 0 |
| 3 | |  Barcelona | 38 | 24 | 7 | 7 | 85 | 38 | 47 | 79 | G19:00 | 22/05/21 | R 38 Eibar 0 Barcelona 1 M19:30 | 16/05/21 | R 37 Barcelona 1 Celta de Vigo 2 B23:00 | 11/05/21 | R 36 Levante 3 Barcelona 3 B17:15 | 08/05/21 | R 35 Barcelona 0 Atletico Madrid 0 G22:00 | 02/05/21 | R 34 Valencia 2 Barcelona 3 M20:00 | 29/04/21 | R 33 Barcelona 1 Granada 2 |
| 4 | |  Sevilla | 38 | 24 | 5 | 9 | 53 | 33 | 20 | 77 | G22:00 | 23/05/21 | R 38 Sevilla 1 Alaves 0 M19:30 | 16/05/21 | R 37 Villarreal 4 Sevilla 0 G20:00 | 12/05/21 | R 36 Sevilla 1 Valencia 0 B22:00 | 09/05/21 | R 35 Real Madrid 2 Sevilla 2 M22:00 | 03/05/21 | R 34 Sevilla 0 Athletic de Bilbao 1 G19:30 | 25/04/21 | R 32 Sevilla 2 Granada 1 |
| 5 | |  Real Sociedad | 38 | 17 | 11 | 10 | 59 | 38 | 21 | 62 | G19:00 | 22/05/21 | R 38 CA Osasuna 0 Real Sociedad 1 G19:30 | 16/05/21 | R 37 Real Sociedad 4 Real Valladolid 1 M23:00 | 12/05/21 | R 36 Atletico Madrid 2 Real Sociedad 1 G22:00 | 07/05/21 | R 35 Real Sociedad 2 Elche 0 M19:30 | 01/05/21 | R 34 Huesca 1 Real Sociedad 0 G22:00 | 26/04/21 | R 32 Eibar 0 Real Sociedad 1 |
| 6 | |  Real Betis Balompie | 38 | 17 | 10 | 11 | 50 | 50 | 0 | 61 | G19:00 | 22/05/21 | R 38 Celta de Vigo 2 Real Betis Balompie 3 G19:30 | 16/05/21 | R 37 Real Betis Balompie 1 Huesca 0 B21:00 | 13/05/21 | R 36 Eibar 1 Real Betis Balompie 1 G22:00 | 10/05/21 | R 35 Real Betis Balompie 2 Granada 1 B15:00 | 02/05/21 | R 34 Real Valladolid 1 Real Betis Balompie 1 B22:00 | 24/04/21 | R 32 Real Madrid 0 Real Betis Balompie 0 |
| 7 | |  Villarreal | 38 | 15 | 13 | 10 | 60 | 44 | 16 | 58 | M19:00 | 22/05/21 | R 38 Real Madrid 2 Villarreal 1 G19:30 | 16/05/21 | R 37 Villarreal 4 Sevilla 0 G20:00 | 13/05/21 | R 36 Real Valladolid 0 Villarreal 2 M19:30 | 09/05/21 | R 35 Villarreal 2 Celta de Vigo 4 G17:15 | 02/05/21 | R 34 Villarreal 1 Getafe CF 0 M17:15 | 25/04/21 | R 32 Villarreal 1 Barcelona 2 |
| 8 | |  Celta de Vigo | 38 | 14 | 11 | 13 | 55 | 57 | -2 | 53 | M19:00 | 22/05/21 | R 38 Celta de Vigo 2 Real Betis Balompie 3 G19:30 | 16/05/21 | R 37 Barcelona 1 Celta de Vigo 2 G21:00 | 12/05/21 | R 36 Celta de Vigo 1 Getafe CF 0 G19:30 | 09/05/21 | R 35 Villarreal 2 Celta de Vigo 4 G22:00 | 30/04/21 | R 34 Celta de Vigo 2 Levante 0 G19:30 | 25/04/21 | R 32 Celta de Vigo 2 CA Osasuna 1 |
| 9 | |  Granada | 38 | 13 | 7 | 18 | 47 | 65 | -18 | 46 | B19:30 | 23/05/21 | R 38 Granada 0 Getafe CF 0 M19:30 | 16/05/21 | R 37 Alaves 4 Granada 2 M23:00 | 13/05/21 | R 36 Granada 1 Real Madrid 4 M22:00 | 10/05/21 | R 35 Real Betis Balompie 2 Granada 1 M19:30 | 02/05/21 | R 34 Granada 0 Cadiz 1 G20:00 | 29/04/21 | R 33 Barcelona 1 Granada 2 |
| 10 | |  Athletic de Bilbao | 38 | 11 | 13 | 14 | 46 | 42 | 4 | 46 | M19:00 | 22/05/21 | R 38 Elche 2 Athletic de Bilbao 0 M19:30 | 16/05/21 | R 37 Athletic de Bilbao 0 Real Madrid 1 M21:00 | 12/05/21 | R 36 Huesca 1 Athletic de Bilbao 0 B22:00 | 08/05/21 | R 35 Athletic de Bilbao 2 CA Osasuna 2 G22:00 | 03/05/21 | R 34 Sevilla 0 Athletic de Bilbao 1 B20:00 | 28/04/21 | R 33 Athletic de Bilbao 2 Real Valladolid 2 |
| 11 | |  CA Osasuna | 38 | 11 | 11 | 16 | 37 | 48 | -11 | 44 | M19:00 | 22/05/21 | R 38 CA Osasuna 0 Real Sociedad 1 M19:30 | 16/05/21 | R 37 Atletico Madrid 2 CA Osasuna 1 G20:00 | 11/05/21 | R 36 CA Osasuna 3 Cadiz 2 B22:00 | 08/05/21 | R 35 Athletic de Bilbao 2 CA Osasuna 2 M22:00 | 01/05/21 | R 34 Real Madrid 2 CA Osasuna 0 M19:30 | 25/04/21 | R 32 Celta de Vigo 2 CA Osasuna 1 |
| 12 | |  Cadiz | 38 | 11 | 11 | 16 | 36 | 58 | -22 | 44 | B22:00 | 21/05/21 | R 38 Levante 2 Cadiz 2 M19:30 | 16/05/21 | R 37 Cadiz 1 Elche 3 M20:00 | 11/05/21 | R 36 CA Osasuna 3 Cadiz 2 G19:30 | 08/05/21 | R 35 Cadiz 2 Huesca 1 G19:30 | 02/05/21 | R 34 Granada 0 Cadiz 1 B17:15 | 24/04/21 | R 32 Real Valladolid 1 Cadiz 1 |
| 13 | |  Valencia | 38 | 10 | 13 | 15 | 50 | 53 | -3 | 43 | B19:00 | 22/05/21 | R 38 Huesca 0 Valencia 0 G19:30 | 16/05/21 | R 37 Valencia 4 Eibar 1 M20:00 | 12/05/21 | R 36 Sevilla 1 Valencia 0 G17:15 | 09/05/21 | R 35 Valencia 3 Real Valladolid 0 M22:00 | 02/05/21 | R 34 Valencia 2 Barcelona 3 B19:30 | 24/04/21 | R 32 Valencia 1 Alaves 1 |
| 14 | |  Levante | 38 | 9 | 14 | 15 | 46 | 57 | -11 | 41 | B22:00 | 21/05/21 | R 38 Levante 2 Cadiz 2 M19:30 | 16/05/21 | R 37 Getafe CF 2 Levante 1 B23:00 | 11/05/21 | R 36 Levante 3 Barcelona 3 B15:00 | 08/05/21 | R 35 Alaves 2 Levante 2 M22:00 | 30/04/21 | R 34 Celta de Vigo 2 Levante 0 M15:00 | 24/04/21 | R 32 Elche 1 Levante 0 |
| 15 | |  Getafe CF | 38 | 9 | 11 | 18 | 28 | 43 | -15 | 38 | B19:30 | 23/05/21 | R 38 Granada 0 Getafe CF 0 G19:30 | 16/05/21 | R 37 Getafe CF 2 Levante 1 M21:00 | 12/05/21 | R 36 Celta de Vigo 1 Getafe CF 0 M15:00 | 09/05/21 | R 35 Getafe CF 0 Eibar 1 M17:15 | 02/05/21 | R 34 Villarreal 1 Getafe CF 0 G15:00 | 25/04/21 | R 32 Huesca 0 Getafe CF 2 |
| 16 | |  Alaves | 38 | 9 | 11 | 18 | 36 | 57 | -21 | 38 | M22:00 | 23/05/21 | R 38 Sevilla 1 Alaves 0 G19:30 | 16/05/21 | R 37 Alaves 4 Granada 2 G21:00 | 11/05/21 | R 36 Elche 0 Alaves 2 B15:00 | 08/05/21 | R 35 Alaves 2 Levante 2 M15:00 | 01/05/21 | R 34 Eibar 3 Alaves 0 B19:30 | 24/04/21 | R 32 Valencia 1 Alaves 1 |
| 17 | |  Elche | 38 | 8 | 12 | 18 | 34 | 55 | -21 | 36 | G19:00 | 22/05/21 | R 38 Elche 2 Athletic de Bilbao 0 G19:30 | 16/05/21 | R 37 Cadiz 1 Elche 3 M21:00 | 11/05/21 | R 36 Elche 0 Alaves 2 M22:00 | 07/05/21 | R 35 Real Sociedad 2 Elche 0 M17:15 | 01/05/21 | R 34 Elche 0 Atletico Madrid 1 G15:00 | 24/04/21 | R 32 Elche 1 Levante 0 |
| 18 | |  Huesca | 38 | 7 | 13 | 18 | 34 | 53 | -19 | 34 | B19:00 | 22/05/21 | R 38 Huesca 0 Valencia 0 M19:30 | 16/05/21 | R 37 Real Betis Balompie 1 Huesca 0 G21:00 | 12/05/21 | R 36 Huesca 1 Athletic de Bilbao 0 M19:30 | 08/05/21 | R 35 Cadiz 2 Huesca 1 G19:30 | 01/05/21 | R 34 Huesca 1 Real Sociedad 0 M15:00 | 25/04/21 | R 32 Huesca 0 Getafe CF 2 |
| 19 | |  Real Valladolid | 38 | 5 | 16 | 17 | 34 | 57 | -23 | 31 | M19:00 | 22/05/21 | R 38 Real Valladolid 1 Atletico Madrid 2 M19:30 | 16/05/21 | R 37 Real Sociedad 4 Real Valladolid 1 M20:00 | 13/05/21 | R 36 Real Valladolid 0 Villarreal 2 M17:15 | 09/05/21 | R 35 Valencia 3 Real Valladolid 0 B15:00 | 02/05/21 | R 34 Real Valladolid 1 Real Betis Balompie 1 B20:00 | 28/04/21 | R 33 Athletic de Bilbao 2 Real Valladolid 2 |
| 20 | |  Eibar | 38 | 6 | 12 | 20 | 29 | 52 | -23 | 30 | M19:00 | 22/05/21 | R 38 Eibar 0 Barcelona 1 M19:30 | 16/05/21 | R 37 Valencia 4 Eibar 1 B21:00 | 13/05/21 | R 36 Eibar 1 Real Betis Balompie 1 G15:00 | 09/05/21 | R 35 Getafe CF 0 Eibar 1 G15:00 | 01/05/21 | R 34 Eibar 3 Alaves 0 M22:00 | 26/04/21 | R 32 Eibar 0 Real Sociedad 1 |
