| 1 | |  Shelbourne FC | 27 | 16 | 9 | 2 | 49 | 23 | 26 | 57 | B21:45 | 29/10/21 | R 27  Shelbourne FC 1 University College Dublin 1 M21:45 | 15/10/21 | R 26 Cobh Ramblers 2 Shelbourne FC 0 B21:45 | 08/10/21 | R 25 Shelbourne FC 1 Athlone Town 1 G21:45 | 01/10/21 | R 24 Shelbourne FC 1 Treaty United 0 G21:45 | 24/09/21 | R 23 Cabinteely FC 0 Shelbourne FC 2 G21:45 | 10/09/21 | R 22 Cork City FC 0 Shelbourne FC 2 |
| 2 | |  Galway United FC | 27 | 15 | 6 | 6 | 39 | 25 | 14 | 51 | M21:45 | 29/10/21 | R 27 Cork City FC 3 Galway United FC 0 G21:45 | 22/10/21 | R 25 Galway United FC 1 Bray Wanderers 0 G21:45 | 15/10/21 | R 26 Galway United FC 2 Wexford FC 1 G21:45 | 01/10/21 | R 24 Cobh Ramblers 0 Galway United FC 1 |
| 3 | |  University College Dublin | 27 | 13 | 7 | 7 | 55 | 38 | 17 | 46 | B21:45 | 29/10/21 | R 27 Shelbourne FC 1 University College Dublin 1 G21:45 | 22/10/21 | R 25 University College Dublin 2 Treaty United 1 G21:45 | 15/10/21 | R 26 University College Dublin 1 Cork City FC 0 |
| 4 | |  Treaty United | 27 | 11 | 9 | 7 | 36 | 27 | 9 | 42 | G21:45 | 29/10/21 | R 27 Cabinteely FC 0 Treaty United 2 M21:45 | 22/10/21 | R 25 University College Dublin 2 Treaty United 1 B21:45 | 15/10/21 | R 26 Treaty United 1 Athlone Town 1 M21:45 | 01/10/21 | R 24 Shelbourne FC 1 Treaty United 0 |
| 5 | |  Bray Wanderers | 27 | 9 | 10 | 8 | 36 | 31 | 5 | 37 | M21:45 | 29/10/21 | R 27 Wexford FC 4 Bray Wanderers 2 M21:45 | 22/10/21 | R 25 Galway United FC 1 Bray Wanderers 0 M21:30 | 15/10/21 | R 26 Bray Wanderers 1 Cabinteely FC 2 |
| 6 | |  Cork City FC | 27 | 8 | 9 | 10 | 37 | 28 | 9 | 33 | G21:45 | 29/10/21 | R 27 Cork City FC 3 Galway United FC 0 M21:45 | 15/10/21 | R 26 University College Dublin 1 Cork City FC 0 G21:45 | 08/10/21 | R 25 Cork City FC 4 Wexford FC 0 B21:30 | 01/10/21 | R 24 Bray Wanderers 0 Cork City FC 0 B21:45 | 24/09/21 | R 23 Treaty United 0 Cork City FC 0 M21:45 | 10/09/21 | R 22 Cork City FC 0 Shelbourne FC 2 |
| 7 | |  Athlone Town | 27 | 9 | 6 | 12 | 32 | 43 | -11 | 33 | M21:45 | 29/10/21 | R 27 Athlone Town 1 Cobh Ramblers 2 B21:45 | 15/10/21 | R 26 Treaty United 1 Athlone Town 1 B21:45 | 08/10/21 | R 25 Shelbourne FC 1 Athlone Town 1 G21:45 | 01/10/21 | R 24 Athlone Town 2 Cabinteely FC 1 M21:45 | 24/09/21 | R 23 Athlone Town 0 Wexford FC 2 G21:30 | 10/09/21 | R 22 Bray Wanderers 0 Athlone Town 1 |
| 8 | |  Cobh Ramblers | 27 | 8 | 4 | 15 | 25 | 46 | -21 | 28 | G21:45 | 29/10/21 | R 27 Athlone Town 1 Cobh Ramblers 2 G21:45 | 15/10/21 | R 26 Cobh Ramblers 2 Shelbourne FC 0 G21:45 | 08/10/21 | R 25 Cabinteely FC 1 Cobh Ramblers 2 M21:45 | 01/10/21 | R 24 Cobh Ramblers 0 Galway United FC 1 M21:00 | 25/09/21 | R 23 Cobh Ramblers 1 Bray Wanderers 2 M21:45 | 10/09/21 | R 22 Wexford FC 3 Cobh Ramblers 1 |
| 9 | |  Cabinteely FC | 27 | 8 | 1 | 18 | 26 | 47 | -21 | 25 | M21:45 | 29/10/21 | R 27 Cabinteely FC 0 Treaty United 2 G21:30 | 15/10/21 | R 26 Bray Wanderers 1 Cabinteely FC 2 M21:45 | 08/10/21 | R 25 Cabinteely FC 1 Cobh Ramblers 2 M21:45 | 01/10/21 | R 24 Athlone Town 2 Cabinteely FC 1 M21:45 | 24/09/21 | R 23 Cabinteely FC 0 Shelbourne FC 2 M21:45 | 10/09/21 | R 22 University College Dublin 5 Cabinteely FC 2 |
| 10 | |  Wexford FC | 27 | 6 | 3 | 18 | 29 | 56 | -27 | 21 | G21:45 | 29/10/21 | R 27 Wexford FC 4 Bray Wanderers 2 M21:45 | 15/10/21 | R 26 Galway United FC 2 Wexford FC 1 M21:45 | 08/10/21 | R 25 Cork City FC 4 Wexford FC 0 G21:45 | 01/10/21 | R 24 Wexford FC 2 University College Dublin 1 G21:45 | 24/09/21 | R 23 Athlone Town 0 Wexford FC 2 G21:45 | 10/09/21 | R 22 Wexford FC 3 Cobh Ramblers 1 |
